UniProt Accession

 RAS2_YEAST; P01120; D6W181; Q45U01 

Genbank Protein ID

 K01971; X00528; D37950; DQ115393; Z50161; Z71374; BK006947 

Genbank Nucleotide ID

 AAA34959.1; CAA25207.1; BAA22510.1; AAZ22509.1; CAA90528.1; CAA95974.1; DAA10447.1 

Protein Name

 Ras-like protein 2 

Protein Synonyms/Alias

  

Gene Name

 RAS2 

Gene Synonyms/Alias

 ASC1; CTN5; GLC5; YNL098C; N2198 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
131	KSDLENEKQVSYQDG	ubiquitination	[1, 2]
143	QDGLNMAKQMNAPFL	ubiquitination	[2]
180	DEGGKYNKTLTENDN	ubiquitination	[2]
189	LTENDNSKQTSQDTK	ubiquitination	[2]
196	KQTSQDTKGSGANSV	ubiquitination	[2]
220	MSNAANGKNVNSSTT	ubiquitination	[2]
239	RNASIESKTGLAGNQ	ubiquitination	[1, 2]
251	GNQATNGKTQTDRTN	ubiquitination	[2]
286	NRVNNNSKAGQVSNA	ubiquitination	[2]
294	AGQVSNAKQARKQQA	ubiquitination	[2]
298	SNAKQARKQQAAPGG	ubiquitination	[2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP. 

Sequence Annotation

 NP_BIND 17 24 GTP (By similarity).
 NP_BIND 64 68 GTP (By similarity).
 NP_BIND 123 126 GTP (By similarity).
 MOTIF 39 47 Effector region (By similarity).
 MOD_RES 198 198 Phosphoserine.
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 214 214 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 238 238 Phosphoserine.
 MOD_RES 319 319 Cysteine methyl ester.
 LIPID 318 318 S-palmitoyl cysteine.
 LIPID 319 319 S-farnesyl cysteine.  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 322 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IDA:SGD.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0007190; P:activation of adenylate cyclase activity; IDA:SGD.
 GO:0030437; P:ascospore formation; IMP:SGD.
 GO:0000411; P:positive regulation of transcription by galactose; IMP:SGD.
 GO:0007124; P:pseudohyphal growth; IMP:SGD.
 GO:0007265; P:Ras protein signal transduction; TAS:SGD.
 GO:0032880; P:regulation of protein localization; IMP:SGD.
 GO:0001302; P:replicative cell aging; IMP:SGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.