UniProt Accession

 S29A2_HUMAN; Q14542; B3KPY7; O43530; Q52M84; Q96R00; Q9UPE0 

Genbank Protein ID

 X86681; AF029358; AF034102; AK057041; AF401235; AP001107; CH471076; CH471076; BC093634 

Genbank Nucleotide ID

 CAA60380.1; AAC39526.1; AAB97834.1; BAG51849.1; AAK92533.1; EAW74521.1; EAW74519.1; AAH93634.1 

Protein Name

 Equilibrative nucleoside transporter 2 

Protein Synonyms/Alias

 36 kDa nucleolar protein HNP36; Delayed-early response protein 12; Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Hydrophobic nucleolar protein, 36 kDa; Nucleoside transporter, ei-type; Solute carrier family 29 member 2 

Gene Name

 SLC29A2 

Gene Synonyms/Alias

 DER12; ENT2; HNP36 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
226	ARYYLANKSSQAQAQ	ubiquitination	[1]
238	QAQELETKAELLQSD	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. 

Sequence Annotation

 MOD_RES 252 252 Phosphoserine.
 CARBOHYD 48 48 N-linked (GlcNAc...).
 CARBOHYD 57 57 N-linked (GlcNAc...).
 CARBOHYD 225 225 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; TAS:ProtInc.
 GO:0005337; F:nucleoside transmembrane transporter activity; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc.
 GO:0015858; P:nucleoside transport; IDA:UniProtKB. 

Interpro

 IPR002259; Eqnu_transpt. 

Pfam

 PF01733; Nucleoside_tran 

SMART

  

PROSITE

  

PRINTS

 PR01130; DERENTRNSPRT.