UniProt Accession

 D3ZSI8_RAT; D3ZSI8 

Genbank Protein ID

 AABR06019271 

Genbank Nucleotide ID

  

Protein Name

 Phosphatidylinositol 4-phosphate 5-kinase type-1 beta 

Protein Synonyms/Alias

  

Gene Name

 Pip5k1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
87	TVGSLSTKPERDVLM	ubiquitination	[1]
124	HYNDFRFKTYAPVAF	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 546 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:Compara.
 GO:0016607; C:nuclear speck; IEA:Compara.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:Compara.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:Compara.
 GO:0032863; P:activation of Rac GTPase activity; IEA:Compara.
 GO:0060326; P:cell chemotaxis; IEA:Compara.
 GO:0010761; P:fibroblast migration; IEA:Compara.
 GO:0048041; P:focal adhesion assembly; IEA:Compara.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:GOC.
 GO:0008654; P:phospholipid biosynthetic process; IEA:Compara.
 GO:0072661; P:protein targeting to plasma membrane; IEA:Compara.
 GO:0097178; P:ruffle assembly; IEA:Compara. 

Interpro

 IPR023610; PInositol-4-P-5-kinase.
 IPR027483; PInositol-4-P-5-kinase_C.
 IPR002498; PInositol-4-P-5-kinase_core.
 IPR027484; PInositol-4-P-5-kinase_N.
 IPR016034; PInositol-4P-5-kinase_core_sub. 

Pfam

 PF01504; PIP5K 

SMART

 SM00330; PIPKc 

PROSITE

 PS51455; PIPK 

PRINTS