CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016278
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Membrane progestin receptor alpha 
Protein Synonyms/Alias
 mPR alpha; Progestin and adipoQ receptor family member 7; Progestin and adipoQ receptor family member VII 
Gene Name
 PAQR7 
Gene Synonyms/Alias
 MRPA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
197CYNKYIQKPGLLGRTubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation. 
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; Developmental protein; Differentiation; Lipid-binding; Membrane; Oogenesis; Polymorphism; Receptor; Reference proteome; Steroid-binding; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF 60
YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG DPHALPLFII VLASFTYLSF 120
SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ FGSALAHFYY AIEPAWHAQV QAVFLPMAAF 180
LAWLSCIGSC YNKYIQKPGL LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY 240
HKCQVVFFLL AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR 300
RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK 346 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0048477; P:oogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR004254; HlyIII-related. 
Pfam
 PF03006; HlyIII 
SMART
  
PROSITE
  
PRINTS