CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NIF3-like protein 1 
Protein Synonyms/Alias
 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein 
Gene Name
 NIF3L1 
Gene Synonyms/Alias
 ALS2CR1; MDS015; My018 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
109RITWNTWKERLVIRAacetylation[1]
109RITWNTWKERLVIRAubiquitination[2, 3, 4]
216INLNCTQKALMQVVDubiquitination[3]
234RNKQLYQKTEILSLEubiquitination[2, 4]
242TEILSLEKPLLLHTGubiquitination[2, 4]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 MOD_RES 109 109 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MLSSCVRPVP TTVRFVDSLI CNSSRSFMDL KALLSSLNDF ASLSFAESWD NVGLLVEPSP 60
PHTVNTLFLT NDLTEEVMEE VLQKKADLIL SYHPPIFRPM KRITWNTWKE RLVIRALENR 120
VGIYSPHTAY DAAPQGVNNW LAKGLGACTS RPIHPSKAPN YPTEGNHRVE FNVNYTQDLD 180
KVMSAVKGID GVSVTSFSAR TGNEEQTRIN LNCTQKALMQ VVDFLSRNKQ LYQKTEILSL 240
EKPLLLHTGM GRLCTLDESV SLATMIDRIK RHLKLSHIRL ALGVGRTLES QVKVVALCAG 300
SGSSVLQGVE ADLYLTGEMS HHDTLDAASQ GINVILCEHS NTERGFLSDL RDMLDSHLEN 360
KINIILSETD RDPLQVV 377 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL. 
Interpro
 IPR002678; Interacting_NIF3.
 IPR017222; UCP037490_NIF3_euk. 
Pfam
 PF01784; NIF3 
SMART
  
PROSITE
  
PRINTS