UniProt Accession

 HIUH_MOUSE; Q9CRB3 

Genbank Protein ID

 DQ225768; AK004470; AK013117; BC051545 

Genbank Nucleotide ID

 ABB46375.1; BAB23318.1; BAB28659.1; AAH51545.1 

Protein Name

 5-hydroxyisourate hydrolase 

Protein Synonyms/Alias

 HIU hydrolase; HIUHase; Transthyretin-related protein 

Gene Name

 Urah 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	LLTPSQIKPGTYKLF	ubiquitination	[1]
67	QIKPGTYKLFFDTER	ubiquitination	[1]
100	TITKETQKFHVPLLL	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). 

Sequence Annotation

 BINDING 11 11 Substrate (By similarity).
 BINDING 51 51 Substrate (By similarity).
 BINDING 115 115 Substrate (By similarity).  

Keyword

 Complete proteome; Hydrolase; Peroxisome; Purine metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IDA:MGI.
 GO:0033971; F:hydroxyisourate hydrolase activity; IEA:EC.
 GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:InterPro.
 GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR014306; Hydroxyisourate_hydrolase.
 IPR000895; Transthyretin/HIU_hydrolase.
 IPR023416; Transthyretin/HIU_hydrolase_SF.
 IPR023419; Transthyretin_CS. 

Pfam

 PF00576; Transthyretin 

SMART

 SM00095; TR_THY 

PROSITE

 PS00768; TRANSTHYRETIN_1
 PS00769; TRANSTHYRETIN_2 

PRINTS

 PR00189; TRNSTHYRETIN.