| Tag | Content |
|---|
| CPLM ID | CPLM-012753 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
Protein Synonyms/Alias | 6PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56; iPFK-2; 6-phosphofructo-2-kinase; Fructose-2,6-bisphosphatase |
Gene Name | PFKFB3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 116 | DVKSYLAKEGGQIAV | ubiquitination | [1] | | 292 | FVEEQNLKDLRVWTS | ubiquitination | [1] | | 302 | RVWTSQLKSTIQTAE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Synthesis and degradation of fructose 2,6-bisphosphate. |
Sequence Annotation | NP_BIND 42 49 ATP (By similarity).
REGION 1 245 6-phosphofructo-2-kinase.
REGION 246 520 Fructose-2,6-bisphosphatase.
ACT_SITE 125 125 Potential.
ACT_SITE 155 155 Potential.
ACT_SITE 254 254 Tele-phosphohistidine intermediate (By
ACT_SITE 323 323 Potential.
ACT_SITE 388 388 Proton donor (By similarity).
BINDING 99 99 Fructose-6-phosphate (By similarity).
BINDING 190 190 Fructose-6-phosphate (By similarity).
MOD_RES 461 461 Phosphoserine; by AMPK.
MOD_RES 463 463 Phosphothreonine.
MOD_RES 467 467 Phosphoserine.
MOD_RES 471 471 Phosphothreonine; by PKC (By similarity). |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Hydrolase; Kinase; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN 60
WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMKVRK QCALAALRDV KSYLAKEGGQ 120
IAVFDATNTT RERRHMILHF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS 180
AEAMDDFMKR ISCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM 240
NIHVQPRTIY LCRHGENEHN LQGRIGGDSG LSSRGKKFAS ALSKFVEEQN LKDLRVWTSQ 300
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG 360
ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL 420
TPVAYGCRVE SIYLNVESVC THRERSEDAK KGPNPLMRRN SVTPLASPEP TKKPRINSFE 480
EHVASTSAAL PSCLPPEVPT QLPGQPLLGQ ACLT 514 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0003873; F:6-phosphofructo-2-kinase activity; NAS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC. GO:0006003; P:fructose 2,6-bisphosphate metabolic process; NAS:UniProtKB. GO:0006000; P:fructose metabolic process; IEA:InterPro. GO:0006096; P:glycolysis; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |