UniProt Accession

 NDUS4_RAT; Q5XIF3; A1L111 

Genbank Protein ID

 BC083729; BC127458 

Genbank Nucleotide ID

 AAH83729.1; AAI27459.1 

Protein Name

 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 

Protein Synonyms/Alias

 Complex I-18 kDa; CI-18 kDa; NADH-ubiquinone oxidoreductase 18 kDa subunit 

Gene Name

 Ndufs4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
73	GVPEEHIKTRKVRIF	acetylation	[1]
95	QSGVNNTKKWKMEFD	acetylation	[1]
96	SGVNNTKKWKMEFDT	acetylation	[1]
98	VNNTKKWKMEFDTRE	acetylation	[1]
168	GANFSWNKRTRVSTK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0045271; C:respiratory chain complex I; IDA:RGD.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:RGD.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0019933; P:cAMP-mediated signaling; IEA:Compara.
 GO:0045333; P:cellular respiration; IEA:Compara.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Compara.
 GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Compara.
 GO:0072593; P:reactive oxygen species metabolic process; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara. 

Interpro

 IPR006885; NADH_UbQ_FeS_4_mit. 

Pfam

 PF04800; ETC_C1_NDUFA4 

SMART

  

PROSITE

  

PRINTS