Tag | Content |
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CPLM ID | CPLM-015520 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inhibitor of Bruton tyrosine kinase |
Protein Synonyms/Alias | IBtk |
Gene Name | Ibtk |
Gene Synonyms/Alias | Kiaa1417 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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461 | TQDGEGFKGKWFEDK | ubiquitination | [1] | 930 | DLSIFYRKMIPAMER | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity). |
Sequence Annotation | REPEAT 51 80 ANK 1. REPEAT 85 114 ANK 2. REPEAT 141 194 RCC1 1. REPEAT 195 246 RCC1 2. REPEAT 248 301 RCC1 3. DOMAIN 565 645 BTB 1. DOMAIN 769 837 BTB 2. MOD_RES 991 991 Phosphoserine (By similarity). MOD_RES 998 998 Phosphothreonine. MOD_RES 1005 1005 Phosphoserine (By similarity). MOD_RES 1046 1046 Phosphoserine. MOD_RES 1055 1055 Phosphoserine (By similarity). MOD_RES 1113 1113 Phosphoserine (By similarity). MOD_RES 1116 1116 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1352 AA |
Protein Sequence | MDAATPDCTS KCRSLKHALD VLSVVTKGSE SQIKSFLARY CYNAATVKDA FGRNAGHLAS 60 SCGKKGVLDW LIEKGVDLLV KDKESGWTAL HRSVFYGHID CVWSLLKHGV SLYMQDKEGL 120 SPLDLLMKDR PTHVVFKDTD PTEVYTWGDN TNFTLGHGSQ NSKHHPELLD LFSRSGVYVK 180 QVVLCKFHSV FLSQKGQVYT CGHGRGGRLG HGDEQTCLVP RLVEGLSGHN CSQVAAAKDH 240 TVVLTDDGCV YTFGLNMFHQ LGIIPPPASC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 300 REAVYTLGLN GGQLGHLLDP NGEKCVTTPR QVSALHHKDI AVSLVAASDG ATVCVTTRGD 360 IYLLADYQCK KMATKQLNLK KVLVSGGCME YKVDPEHLTE NGGQKICVLA MDGAGRVFCW 420 RSISSSLKQC RWAYPRQVSI SDIALNRNEI LFVTQDGEGF KGKWFEDKRK NSEKKADILP 480 NLHHSSSDVS CVPDTNSVYE RIRLEKLPFA HRAVSVSTDP SGCNFAILQS DPKTSLYEIP 540 VVSSSSFFEE FGKLLRETDE MDSFHDVTFQ VGNRHFPAHK YILAVRSDFF QKLFLSDGSS 600 LELTDVYQKD EDAAGCHLFV VEKVHPDLFE YLLQFMYTDT CDLLTHGFKP RMIVKRKAED 660 CEGSPDSHLH TVNCHVDDKQ KSAFEVYRSN QAHTLSERQK SKPKSSKKGK GVGDDDPVRM 720 LQSVAKKFGL SNLSSRLEGV RLENEKINVI AKKTGNKLKL SQKKCSFLYD VTMKSVDGKE 780 FSCHKCVLCA RLEYFHSMLS RSWIEASSCA ALEMPIQSEI LKVILDYLYT DEAVVIKESQ 840 NVDFVCSVLV VADQLLITRL KEICEVALTE NLTLKNAAML LEFAALYNAG QLKLSCLQFI 900 GLNMAALLEA RSLDVLSEDV LKDLSIFYRK MIPAMERRVI TPYQDGPDIS SMQVEDGEVF 960 FKEEINMEPN YSETMFKKAK TRAKKKPRKR SDSSGGYTLS DVIQSPPSAG LLKSAKTNSV 1020 ESLPELLTSD SEGSYAGVAS PRDLQSPDFT AGFHSDKVEG KAKPYVNGIP PPCTREDVKP 1080 WEKSPTTKSA PQFIPSNRVD TAASSSWLAG SCSPVSPPVV DLRTIMETEE NRQKYGAAPK 1140 SNLGKIISHG IKLSQKQRKM IALTTKENNS GTNSMEAILT APSKSPKPAN AWAPLHSPLS 1200 RSFRDFLLEE KKPVPGYGSG DHVKKVCFKG TENSPALNVA RCSTHGTPGL ESNHVSDFPL 1260 LDSPNPWQSS SLAASPAVAP VTFASIVEEE RQQEAALIRS REKPLALIQV EEHAIQDLLV 1320 FYEAFGNPEE FVVVERAPQG PLAVPMWNKH GC 1352 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0030292; F:protein tyrosine kinase inhibitor activity; IEA:Compara. GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |