CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045256
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear pore glycoprotein p62 
Protein Synonyms/Alias
  
Gene Name
 NUP62 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
295TLIENGEKITSLHREacetylation[1]
295TLIENGEKITSLHREubiquitination[2, 3, 4]
359EEREKTYKLAENIDAubiquitination[2]
369ENIDAQLKRMAQDLKubiquitination[3, 4, 5]
422NSALLQRKVEEVTKVubiquitination[4]
428RKVEEVTKVCEGRRKubiquitination[3, 4, 6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF 60
SLATQTPATQ TTGFTFGTAT LASGGTGFSL GIGASKLNLS NTAATPAMAN PSGFGLGSSN 120
LTNAISSTVT SSQGTAPTGF VFGPSTTSVA PATTSGGFSF TGGSTAQPSG FNIGSAGNSA 180
QPTAPATLPF TPATPAATTA GATQPAAPTP TATITSTGPS LFASIATAPT SSATTGLSLC 240
TPVTTAGAPT AGTQGFSLKA PGAASGTSTT TSTAATATAT QVNAWDRTLI ENGEKITSLH 300
REVEKVKLDQ KRLDQELDFI LSQQKELEDL LSPLEELVKE QSGTIYLQHA DEEREKTYKL 360
AENIDAQLKR MAQDLKDIIE HLNTSGAPAD TSDPLQQICK ILNAHMDSLQ WIDQNSALLQ 420
RKVEEVTKVC EGRRKEQERS FRITFD 446 
Gene Ontology
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro. 
Interpro
 IPR026010; NSP1/NUP62.
 IPR007758; Nucleoporin_NSP1_C. 
Pfam
 PF05064; Nsp1_C 
SMART
  
PROSITE
  
PRINTS