CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000489
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor tyrosine-protein kinase erbB-2 
Protein Synonyms/Alias
 Proto-oncogene c-ErbB-2; p185erbB2; CD340 
Gene Name
 ERBB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Canis familiaris (Dog) (Canis lupus familiaris) 
NCBI Taxa ID
 9615 
Lysine Modification
Position
Peptide
Type
References
936EIPDLLEKGERLPQPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). 
Sequence Annotation
 DOMAIN 719 986 Protein kinase.
 NP_BIND 725 733 ATP (By similarity).
 REGION 675 688 Nuclear localization signal (By
 REGION 675 688 Required for interaction with KPNB1 and
 REGION 1199 1201 Interaction with PIK3C2B (By similarity).
 ACT_SITE 844 844 Proton acceptor (By similarity).
 BINDING 752 752 ATP (By similarity).
 MOD_RES 1106 1106 Phosphoserine (By similarity).
 MOD_RES 1138 1138 Phosphotyrosine; by autocatalysis (By
 MOD_RES 1200 1200 Phosphotyrosine (Potential).
 MOD_RES 1252 1252 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
 CARBOHYD 259 259 N-linked (GlcNAc...) (Potential).
 CARBOHYD 421 421 N-linked (GlcNAc...) (Potential).
 CARBOHYD 529 529 N-linked (GlcNAc...) (Potential).
 CARBOHYD 570 570 N-linked (GlcNAc...) (Potential).
 CARBOHYD 628 628 N-linked (GlcNAc...) (Potential).
 DISULFID 26 53 By similarity.
 DISULFID 162 192 By similarity.
 DISULFID 195 204 By similarity.
 DISULFID 199 212 By similarity.
 DISULFID 220 227 By similarity.
 DISULFID 224 235 By similarity.
 DISULFID 236 244 By similarity.
 DISULFID 240 252 By similarity.
 DISULFID 255 264 By similarity.
 DISULFID 268 295 By similarity.
 DISULFID 299 311 By similarity.
 DISULFID 315 331 By similarity.
 DISULFID 334 338 By similarity.
 DISULFID 342 367 By similarity.
 DISULFID 475 504 By similarity.
 DISULFID 511 519 By similarity.
 DISULFID 514 527 By similarity.
 DISULFID 530 539 By similarity.
 DISULFID 543 559 By similarity.
 DISULFID 562 575 By similarity.
 DISULFID 566 583 By similarity.
 DISULFID 586 595 By similarity.
 DISULFID 599 622 By similarity.
 DISULFID 625 633 By similarity.
 DISULFID 629 641 By similarity.  
Keyword
 Activator; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1259 AA 
Protein Sequence
MELAAWCRWG LLLALLPSGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 60
ELTYLPANAS LSFLQDIQEV QGYVLIAHSQ VRQIPLQRLR IVRGTQLFED NYALAVLDNG 120
DPLEGGIPAP GAAQGGLREL QLRSLTEILK GGVLIQRSPQ LCHQDTILWK DVFHKNNQLA 180
LTLIDTNRFS ACPPCSPACK DAHCWGASSG DCQSLTRTVC AGGCARCKGP QPTDCCHEQC 240
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTSCP 300
YNYLSTDVGS CTLVCPLNNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 360
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLRVF EALEEITGYL YISAWPDSLP 420
NLSVFQNLRV IRGRVLHDGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHR NARLCFVHTV 480
PWDQLFRNPH QALLHSANRP EEECVGEGLA CYPCAHGHCW GPGPTQCVNC SQFLRGQECV 540
EECRVLQGLP REYVKDRYCL PCHSECQPQN GSVTCFGSEA DQCVACAHYK DPPFCVARCP 600
SGVKPDLSFM PIWKFADEEG TCQPCPINCT HSCADLDEKG CPAEQRASPV TSIIAAVVGI 660
LLAVVVGLVL GILIKRRRQK IRKYTMRRLL QETELVEPLT PSGAMPNQAQ MRILKETELR 720
KVKVLGSGAF GTVYKGIWIP DGENVKIPVA IKVLRENTSP KANKEILDEA YVMAGVGSPY 780
VSRLLGICLT STVQLVTQLM PYGCLLDHVR EHRGRLGSQD LLNWCVQIAK GMSYLEDVRL 840
VHRDLAARNV LVKSPNHVKI TDFGLARLLD IDETEYHADG GKVPIKWMAL ESIPPRRFTH 900
QSDVWSYGVT VWELMTFGAK PYDGIPAREI PDLLEKGERL PQPPICTIDV YMIMVKCWMI 960
DSECRPRFRE LVAEFSRMAR DPQRFVVIQN EDLGPASPLD STFYRSLLED DDMGDLVDAE 1020
EYLVPQQGFF CPEPTPGAGG TAHRRHRSSS TRNGGGELTL GLEPSEEEPP KSPLAPSEGA 1080
GSDVFDGDLG MGAAKGLQSL PSQDPSPLQR YSEDPTVPLP PETDGKVAPL TCSPQPEYVN 1140
QPEVWPQPPL ALEGPLPPSR PAGATLERPK TLSPKTLSPG KNGVVKDVFA FGSAVENPEY 1200
LAPRGRAAPQ PHPPPAFSPA FDNLYYWDQD PSERGSPPST FEGTPTAENP EYLGLDVPV 1259 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004716; F:receptor signaling protein tyrosine kinase activity; IEA:InterPro.
 GO:0001042; F:RNA polymerase I core binding; ISS:UniProtKB.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
 GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; ISS:UniProtKB.
 GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; ISS:UniProtKB.
 GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
 GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
 GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 
Interpro
 IPR000494; EGF_rcpt_L.
 IPR006211; Furin-like_Cys-rich_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt. 
Pfam
 PF00757; Furin-like
 PF07714; Pkinase_Tyr
 PF01030; Recep_L_domain 
SMART
 SM00261; FU
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.