UniProt Accession

 APOA1_HUMAN; P02647; A8K866; Q6LDN9; Q6Q785; Q9UCS8; Q9UCT8 

Genbank Protein ID

 J00098; X01038; X02162; X00566; M11791; X07496; M27875; M29068; AY422952; AY555191; A14829; AK292231; EF444948; EF444948; EF444948; EF444948; EF444948; CH471065; BC005380; BC110286 

Genbank Nucleotide ID

 AAB59514.1; CAA25519.1; CAA26097.1; CAA25232.1; AAA35545.1; CAA30377.1; AAA62829.1; AAA51747.1; AAQ91811.1; AAS68227.1; CAA01198.1; BAF84920.1; ACA05932.1; ACA05933.1; ACA05934.1; ACA05935.1; ACA05936.1; EAW67274.1; AAH05380.1; AAI10287.1 

Protein Name

 Apolipoprotein A-I 

Protein Synonyms/Alias

 Apo-AI; ApoA-I; Apolipoprotein A1; Truncated apolipoprotein A-I; Apolipoprotein A-I(1-242) 

Gene Name

 APOA1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	QSPWDRVKDLATVYV	glycation	[1]
47	TVYVDVLKDSGRDYV	glycation	[1]
120	DLEEVKAKVQPYLDD	glycation	[1]
130	PYLDDFQKKWQEEME	glycation	[1]
131	YLDDFQKKWQEEMEL	glycation	[1]
157	LQEGARQKLHELQEK	glycation	[1]
164	KLHELQEKLSPLGEE	glycation	[1]
206	AARLEALKENGGARL	glycation	[1]
219	RLAEYHAKATEHLST	glycation	[1]
263	ALEEYTKKLNTQ***	glycation	[2]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901]
 [2] The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo.
 Calvo C, Ulloa N, Campos M, Verdugo C, Ayrault-Jarrier M.
 Clin Chim Acta. 1993 Aug 31;217(2):193-8. [PMID: 8261628] 

Functional Description

 Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. 

Sequence Annotation

 REPEAT 68 89 1.
 REPEAT 90 111 2.
 REPEAT 112 122 3; half-length.
 REPEAT 123 144 4.
 REPEAT 145 166 5.
 REPEAT 167 188 6.
 REPEAT 189 210 7.
 REPEAT 211 232 8.
 REPEAT 233 243 9; half-length.
 REPEAT 244 267 10.
 REGION 68 267 10 X approximate tandem repeats.
 MOD_RES 110 110 Methionine sulfoxide.
 MOD_RES 136 136 Methionine sulfoxide.
 CARBOHYD 263 263 N-linked (Glc) (glycation).  

Keyword

 3D-structure; Amyloid; Amyloidosis; Atherosclerosis; Cholesterol metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Glycation; Glycoprotein; HDL; Lipid metabolism; Lipid transport; Lipoprotein; Neuropathy; Oxidation; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005769; C:early endosome; TAS:Reactome.
 GO:0030139; C:endocytic vesicle; IDA:BHF-UCL.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0034774; C:secretory granule lumen; TAS:Reactome.
 GO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL.
 GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
 GO:0001540; F:beta-amyloid binding; IDA:BHF-UCL.
 GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
 GO:0017127; F:cholesterol transporter activity; IMP:BHF-UCL.
 GO:0008035; F:high-density lipoprotein particle binding; IEA:Compara.
 GO:0055102; F:lipase inhibitor activity; IEA:Compara.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL.
 GO:0005543; F:phospholipid binding; IDA:BHF-UCL.
 GO:0005548; F:phospholipid transporter activity; IEA:Compara.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; IEA:Compara.
 GO:0006695; P:cholesterol biosynthetic process; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
 GO:0070508; P:cholesterol import; IMP:BHF-UCL.
 GO:0008203; P:cholesterol metabolic process; IMP:BHF-UCL.
 GO:0001935; P:endothelial cell proliferation; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
 GO:0008211; P:glucocorticoid metabolic process; IEA:Compara.
 GO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL.
 GO:0034384; P:high-density lipoprotein particle clearance; IC:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; IC:BHF-UCL.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0042158; P:lipoprotein biosynthetic process; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0060354; P:negative regulation of cell adhesion molecule production; IDA:BHF-UCL.
 GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IDA:BHF-UCL.
 GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL.
 GO:0050728; P:negative regulation of inflammatory response; IDA:BHF-UCL.
 GO:0050713; P:negative regulation of interleukin-1 beta secretion; IDA:BHF-UCL.
 GO:0060192; P:negative regulation of lipase activity; IEA:Compara.
 GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IDA:BHF-UCL.
 GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IDA:BHF-UCL.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0018206; P:peptidyl-methionine modification; IDA:UniProtKB.
 GO:0014012; P:peripheral nervous system axon regeneration; IEA:Compara.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IDA:BHF-UCL.
 GO:0033700; P:phospholipid efflux; IDA:BHF-UCL.
 GO:0055091; P:phospholipid homeostasis; IDA:BHF-UCL.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL.
 GO:0051345; P:positive regulation of hydrolase activity; IDA:BHF-UCL.
 GO:0051347; P:positive regulation of transferase activity; IEA:Compara.
 GO:0018158; P:protein oxidation; IDA:UniProtKB.
 GO:0050821; P:protein stabilization; IDA:BHF-UCL.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IDA:BHF-UCL.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0043691; P:reverse cholesterol transport; IMP:BHF-UCL.
 GO:0070328; P:triglyceride homeostasis; IDA:BHF-UCL. 

Interpro

 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 

Pfam

 PF01442; Apolipoprotein 

SMART

  

PROSITE

  

PRINTS