UniProt Accession

 SEH1_MOUSE; Q8R2U0; Q3TLC9; Q3UP79; Q9D0K7 

Genbank Protein ID

 AK011330; AK088835; AK143727; AK166573; AK169231; AK169388; AK170591; CH466528; CH466528; BC027244 

Genbank Nucleotide ID

 BAB27549.1; BAC40603.1; BAE25518.1; BAE38863.1; BAE41000.1; BAE41135.1; BAE41899.1; EDL09627.1; EDL09628.1; AAH27244.1 

Protein Name

 Nucleoporin SEH1 

Protein Synonyms/Alias

 Nup107-160 subcomplex subunit SEH1 

Gene Name

 Seh1l 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	RSIAADHKDLIHDVS	ubiquitination	[1]
96	IVGESNDKLRGQSHW	ubiquitination	[1]
251	DVRIFTLKPLRKELT	acetylation	[2]
314	ANYMDNWKCTGILKG	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (By similarity). 

Sequence Annotation

 REPEAT 10 49 WD 1.
 REPEAT 55 96 WD 2.
 REPEAT 111 152 WD 3.
 REPEAT 160 210 WD 4.
 REPEAT 217 258 WD 5.
 REPEAT 276 315 WD 6.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
 GO:0051315; P:attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006999; P:nuclear pore organization; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.