CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002030
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bacteriorhodopsin 
Protein Synonyms/Alias
 BR; Bacterioopsin; BO 
Gene Name
 bop 
Gene Synonyms/Alias
 VNG_1467G 
Created Date
 July 27, 2013 
Organism
 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1 
NCBI Taxa ID
 64091 
Lysine Modification
Position
Peptide
Type
References
43GTLYFLVKGMGVSDPacetylation[1]
53GVSDPDAKKFYAITTacetylation[1]
54VSDPDAKKFYAITTLacetylation[1]
142GLVGALTKVYSYRFVacetylation[2]
Reference
 [1] Regeneration of native bacteriorhodopsin structure following acetylation of epsilon-amino groups of Lys-30, -40, and -41.
 Abercrombie DM, Khorana HG.
 J Biol Chem. 1986 Apr 15;261(11):4875-80. [PMID: 3007477]
 [2] On the protein residues that control the yield and kinetics of O(630) in the photocycle of bacteriorhodopsin.
 Li Q, Bressler S, Ovrutsky D, Ottolenghi M, Friedman N, Sheves M.
 Biophys J. 2000 Jan;78(1):354-62. [PMID: 10620299
Functional Description
 Light-driven proton pump. 
Sequence Annotation
 MOD_RES 14 14 Pyrrolidone carboxylic acid.
 MOD_RES 229 229 N6-(retinylidene)lysine.  
Keyword
 3D-structure; Cell membrane; Chromophore; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Photoreceptor protein; Pyrrolidone carboxylic acid; Receptor; Reference proteome; Retinal protein; Sensory transduction; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 262 AA 
Protein Sequence
MLELLPTAVE GVSQAQITGR PEWIWLALGT ALMGLGTLYF LVKGMGVSDP DAKKFYAITT 60
LVPAIAFTMY LSMLLGYGLT MVPFGGEQNP IYWARYADWL FTTPLLLLDL ALLVDADQGT 120
ILALVGADGI MIGTGLVGAL TKVYSYRFVW WAISTAAMLY ILYVLFFGFT SKAESMRPEV 180
ASTFKVLRNV TVVLWSAYPV VWLIGSEGAG IVPLNIETLL FMVLDVSAKV GFGLILLRSR 240
AIFGEAEAPE PSAGDGAAAT SD 262 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005216; F:ion channel activity; IEA:InterPro.
 GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
 GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
 GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
 GO:0015992; P:proton transport; IEA:UniProtKB-KW. 
Interpro
 IPR001425; Rhodopsin_arc/bac/fun.
 IPR018229; Rhodopsin_retinal_BS. 
Pfam
 PF01036; Bac_rhodopsin 
SMART
 SM01021; Bac_rhodopsin 
PROSITE
 PS00950; BACTERIAL_OPSIN_1
 PS00327; BACTERIAL_OPSIN_RET 
PRINTS
 PR00251; BACTRLOPSIN.