CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Collagen alpha-1(XVII) chain 
Protein Synonyms/Alias
 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2; 120 kDa linear IgA disease antigen; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-1; 97 kDa linear IgA disease antigen; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa; LABD97 
Gene Name
 COL17A1 
Gene Synonyms/Alias
 BP180; BPAG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
389SFSEDTLKKEKQAAYubiquitination[1]
403YNADSGLKAEANGDLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. 
Sequence Annotation
 REGION 1 566 Nonhelical region (NC16).
 REGION 145 230 Necessary for interaction with DST and
 REGION 567 1482 Triple-helical region.
 REGION 1483 1497 Nonhelical region (NC1).
 MOD_RES 85 85 Phosphoserine (By similarity).
 MOD_RES 93 93 Phosphoserine (By similarity).
 MOD_RES 148 148 Phosphoserine (By similarity).
 MOD_RES 544 544 Phosphoserine; by CK2.
 CARBOHYD 1421 1421 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Basement membrane; Cell junction; Collagen; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Epidermolysis bullosa; Extracellular matrix; Glycoprotein; Hydroxylation; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1497 AA 
Protein Sequence
MDVTKKNKRD GTEVTERIVT ETVTTRLTSL PPKGGTSNGY AKTASLGGGS RLEKQSLTHG 60
SSGYINSTGS TRGHASTSSY RRAHSPASTL PNSPGSTFER KTHVTRHAYE GSSSGNSSPE 120
YPRKEFASSS TRGRSQTRES EIRVRLQSAS PSTRWTELDD VKRLLKGSRS ASVSPTRNSS 180
NTLPIPKKGT VETKIVTASS QSVSGTYDAT ILDANLPSHV WSSTLPAGSS MGTYHNNMTT 240
QSSSLLNTNA YSAGSVFGVP NNMASCSPTL HPGLSTSSSV FGMQNNLAPS LTTLSHGTTT 300
TSTAYGVKKN MPQSPAAVNT GVSTSAACTT SVQSDDLLHK DCKFLILEKD NTPAKKEMEL 360
LIMTKDSGKV FTASPASIAA TSFSEDTLKK EKQAAYNADS GLKAEANGDL KTVSTKGKTT 420
TADIHSYGSS GGGGSGGGGG VGGAGGGPWG PAPAWCPCGS CCSWWKWLLG LLLTWLLLLG 480
LLFGLIALAE EVRKLKARVD ELERIRRSIL PYGDSMDRIE KDRLQGMAPA AGADLDKIGL 540
HSDSQEELWM FVRKKLMMEQ ENGNLRGSPG PKGDMGSPGP KGDRGFPGTP GIPGPLGHPG 600
PQGPKGQKGS VGDPGMEGPM GQRGREGPMG PRGEAGPPGS GEKGERGAAG EPGPHGPPGV 660
PGSVGPKGSS GSPGPQGPPG PVGLQGLRGE VGLPGVKGDK GPMGPPGPKG DQGEKGPRGL 720
TGEPGMRGLP GAVGEPGAKG AMGPAGPDGH QGPRGEQGLT GMPGIRGPPG PSGDPGKPGL 780
TGPQGPQGLP GTPGRPGIKG EPGAPGKIVT SEGSSMLTVP GPPGPPGAMG PPGPPGAPGP 840
AGPAGLPGHQ EVLNLQGPPG PPGPRGPPGP SIPGPPGPRG PPGEGLPGPP GPPGSFLSNS 900
ETFLSGPPGP PGPPGPKGDQ GPPGPRGHQG EQGLPGFSTS GSSSFGLNLQ GPPGPPGPQG 960
PKGDKGDPGV PGALGIPSGP SEGGSSSTMY VSGPPGPPGP PGPPGSISSS GQEIQQYISE 1020
YMQSDSIRSY LSGVQGPPGP PGPPGPVTTI TGETFDYSEL ASHVVSYLRT SGYGVSLFSS 1080
SISSEDILAV LQRDDVRQYL RQYLMGPRGP PGPPGASGDG SLLSLDYAEL SSRILSYMSS 1140
SGISIGLPGP PGPPGLPGTS YEELLSLLRG SEFRGIVGPP GPPGPPGIPG NVWSSISVED 1200
LSSYLHTAGL SFIPGPPGPP GPPGPRGPPG VSGALATYAA ENSDSFRSEL ISYLTSPDVR 1260
SFIVGPPGPP GPQGPPGDSR LLSTDASHSR GSSSSSHSSS VRRGSSYSSS MSTGGGGAGS 1320
LGAGGAFGEA AGDRGPYGTD IGPGGGYGAA AEGGMYAGNG GLLGADFAGD LDYNELAVRV 1380
SESMQRQGLL QGMAYTVQGP PGQPGPQGPP GISKVFSAYS NVTADLMDFF QTYGAIQGPP 1440
GQKGEMGTPG PKGDRGPAGP PGHPGPPGPR GHKGEKGDKG DQVYAGRRRR RSIAVKP 1497 
Gene Ontology
 GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
 GO:0005911; C:cell-cell junction; TAS:ProtInc.
 GO:0005581; C:collagen; IEA:UniProtKB-KW.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0030056; C:hemidesmosome; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0008544; P:epidermis development; TAS:ProtInc.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0031581; P:hemidesmosome assembly; IDA:UniProtKB. 
Interpro
 IPR008160; Collagen. 
Pfam
 PF01391; Collagen 
SMART
  
PROSITE
  
PRINTS