CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secernin-1 
Protein Synonyms/Alias
  
Gene Name
 SCRN1 
Gene Synonyms/Alias
 KIAA0193 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18VAFPPRAKDGLVVFGubiquitination[1]
179GKYWAAEKVTEGVRCubiquitination[2]
306DPSRSIFKPFIFVDDubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). 
Sequence Annotation
 ACT_SITE 9 9 Potential.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Exocytosis; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 414 AA 
Protein Sequence
MAAAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES KVECTYISID 60
QVPRTYAIMI SRPAWLWGAE MGANEHGVCI ANEAINTREP AAEIEALLGM DLVRLGLERG 120
ETAKEALDVI VSLLEEHGQG GNYFEDANSC HSFQSAYLIV DRDEAWVLET IGKYWAAEKV 180
TEGVRCICSQ LSLTTKMDAE HPELRSYAQS QGWWTGEGEF NFSEVFSPVE DHLDCGAGKD 240
SLEKQEESIT VQTMMNTLRD KASGVCIDSE FFLTTASGVS VLPQNRSSPC IHYFTGTPDP 300
SRSIFKPFIF VDDVKLVPKT QSPCFGDDDP AKKEPRFQEK PDRRHELYKA HEWARAIIES 360
DQEQGRKLRS TMLELEKQGL EAMEEILTSS EPLDPAEVGD LFYDCVDTEI KFFK 414 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0016805; F:dipeptidase activity; IEA:InterPro.
 GO:0006887; P:exocytosis; ISS:UniProtKB.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR005322; Peptidase_C69. 
Pfam
 PF03577; Peptidase_C69 
SMART
  
PROSITE
  
PRINTS