UniProt Accession

 F111A_HUMAN; Q96PZ2; A8K5Y8; Q5RKS9; Q5XKM2; Q68DK9; Q6IPR7; Q9H5Y1 

Genbank Protein ID

 AB067482; AK026447; AK291453; CR749358; BC013137; BC054515; BC071759 

Genbank Nucleotide ID

 BAB67788.1; BAB15486.1; BAF84142.1; CAH18211.1; AAH13137.1; AAH54515.1; AAH71759.1 

Protein Name

 Protein FAM111A 

Protein Synonyms/Alias

  

Gene Name

 FAM111A 

Gene Synonyms/Alias

 KIAA1895 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	RKHSVNEKCNMKIEH	ubiquitination	[1]
20	VNEKCNMKIEHYFSP	ubiquitination	[1, 2]
30	HYFSPVSKEQQNNCS	ubiquitination	[1, 2]
64	AQRFHSPKKNPEDQT	ubiquitination	[2]
65	QRFHSPKKNPEDQTM	ubiquitination	[2]
116	NTLQAVRKEIETHQG	ubiquitination	[2]
163	TFSQSKSKQKEDNHI	ubiquitination	[2]
165	SQSKSKQKEDNHIFG	ubiquitination	[1, 2]
270	YFQVEVEKRMVPSAA	ubiquitination	[2]
286	SQNPESEKRNTCVLR	ubiquitination	[2, 3, 4, 5]
304	VAQYPSLKRESEKII	ubiquitination	[1, 2, 5]
309	SLKRESEKIIENFKK	ubiquitination	[2]
315	EKIIENFKKKMKVKN	ubiquitination	[1, 2, 5]
316	KIIENFKKKMKVKNG	ubiquitination	[2, 5]
317	IIENFKKKMKVKNGE	ubiquitination	[2]
321	FKKKMKVKNGETLFE	ubiquitination	[2, 5]
336	LHRTTFGKVTKNSSS	ubiquitination	[2, 5]
480	GHPYGEKKQIDACAV	ubiquitination	[2]
505	QERVQSKKAESPEYV	ubiquitination	[2, 5]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Acts as a Simian virus 40 (SV40) host range restriction factor and can restrict SV40 and adenovirus replication. 

Sequence Annotation

 REGION 336 611 Interaction with SV40 large T antigen.  

Keyword

 Antiviral defense; Complete proteome; Cytoplasm; Disease mutation; Dwarfism; Host-virus interaction; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0000087; P:M phase of mitotic cell cycle; IEP:UniProtKB.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR009003; Trypsin-like_Pept_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS