UniProt Accession

 F8WGL3_MOUSE; F8WGL3 

Genbank Protein ID

 AC126029 

Genbank Nucleotide ID

  

Protein Name

 Cofilin-1 

Protein Synonyms/Alias

  

Gene Name

 Cfl1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	AVSDGVIKVFNDMKV	acetylation	[1]
19	IKVFNDMKVRKSSTP	acetylation	[1, 2]
19	IKVFNDMKVRKSSTP	succinylation	[2]
19	IKVFNDMKVRKSSTP	ubiquitination	[3]
33	PEEVKKRKKAVLFCL	acetylation	[1]
34	EEVKKRKKAVLFCLS	acetylation	[1]
44	LFCLSEDKKNIILEE	acetylation	[1, 2, 4]
44	LFCLSEDKKNIILEE	succinylation	[2]
44	LFCLSEDKKNIILEE	ubiquitination	[3]
45	FCLSEDKKNIILEEG	acetylation	[1]
45	FCLSEDKKNIILEEG	ubiquitination	[3]
53	NIILEEGKEILVGDV	acetylation	[1]
73	DPYTTFVKMLPDKDC	ubiquitination	[3]
78	FVKMLPDKDCRYALY	acetylation	[1]
78	FVKMLPDKDCRYALY	ubiquitination	[3]
92	YDATYETKESKKEDL	acetylation	[2]
92	YDATYETKESKKEDL	succinylation	[2]
92	YDATYETKESKKEDL	ubiquitination	[3]
112	APENAPLKSKMIYAS	ubiquitination	[3]
114	ENAPLKSKMIYASSK	acetylation	[1, 2]
114	ENAPLKSKMIYASSK	succinylation	[2]
121	KMIYASSKDAIKKKL	acetylation	[1, 2]
121	KMIYASSKDAIKKKL	succinylation	[2]
121	KMIYASSKDAIKKKL	ubiquitination	[3]
127	SKDAIKKKLTGIKHE	acetylation	[1]
132	KKKLTGIKHELQANC	acetylation	[1]
144	ANCYEEVKDRCTLAE	acetylation	[1, 2, 4]
144	ANCYEEVKDRCTLAE	succinylation	[2]
144	ANCYEEVKDRCTLAE	ubiquitination	[3]
152	DRCTLAEKLGGSAVI	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Actin-binding; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0030864; C:cortical actin cytoskeleton; IDA:MGI.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0030042; P:actin filament depolymerization; IEA:InterPro.
 GO:0007015; P:actin filament organization; IMP:MGI.
 GO:0030030; P:cell projection organization; ISO:MGI.
 GO:0000910; P:cytokinesis; IMP:MGI.
 GO:0030010; P:establishment of cell polarity; IMP:MGI.
 GO:0045792; P:negative regulation of cell size; ISO:MGI.
 GO:0001755; P:neural crest cell migration; IMP:MGI.
 GO:0001842; P:neural fold formation; IMP:MGI.
 GO:0030836; P:positive regulation of actin filament depolymerization; IMP:MGI.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IDA:MGI.
 GO:0022604; P:regulation of cell morphogenesis; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IDA:MGI.
 GO:0009615; P:response to virus; IEA:Compara. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR017904; ADF/Cofilin/Destrin.
 IPR027234; Cofilin_1/2. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS

 PR00006; COFILIN.