CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003217
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cold shock protein CspA 
Protein Synonyms/Alias
 CSP-A; 7.4 kDa cold shock protein; CS7.4 
Gene Name
 cspA 
Gene Synonyms/Alias
 cspS; b3556; JW3525 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
28ITPDDGSKDVFVHFSacetylation[1]
50KSLDEGQKVSFTIESacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'. 
Sequence Annotation
 DOMAIN 7 67 CSD.  
Keyword
 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Stress response; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 70 AA 
Protein Sequence
MSGKMTGIVK WFNADKGFGF ITPDDGSKDV FVHFSAIQND GYKSLDEGQK VSFTIESGAK 60
GPAAGNVTSL 70 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0001072; F:RNA binding transcription antitermination factor activity; IDA:EcoliWiki.
 GO:0003697; F:single-stranded DNA binding; IDA:EcoliWiki.
 GO:0003727; F:single-stranded RNA binding; IDA:EcoliWiki.
 GO:0060567; P:negative regulation of DNA-dependent transcription, termination; IDA:EcoliWiki.
 GO:0009409; P:response to cold; IEP:EcoliWiki.
 GO:0006351; P:transcription, DNA-dependent; IDA:EcoCyc. 
Interpro
 IPR019844; Cold-shock_CS.
 IPR012156; Cold_shock_CspA.
 IPR011129; Cold_shock_prot.
 IPR002059; CSP_DNA-bd.
 IPR012340; NA-bd_OB-fold. 
Pfam
 PF00313; CSD 
SMART
 SM00357; CSP 
PROSITE
 PS00352; COLD_SHOCK 
PRINTS
 PR00050; COLDSHOCK.