CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009369
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein transport protein Sec61 subunit alpha isoform 1 
Protein Synonyms/Alias
 Sec61 alpha-1 
Gene Name
 Sec61a1 
Gene Synonyms/Alias
 Sec61a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10IKFLEVIKPFCVILPacetylation[1]
392SSAKDVAKQLKEQQMubiquitination[2]
395KDVAKQLKEQQMVMRubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adaptor proteins. 
Sequence Annotation
  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD 60
PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 180
LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 240
NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 360
AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 420
AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF 476 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0043022; F:ribosome binding; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0034341; P:response to interferon-gamma; IEA:Compara. 
Interpro
 IPR002208; SecY/SEC61-alpha.
 IPR023201; SecY_su_dom.
 IPR019561; Translocon_Sec61/SecY_plug_dom. 
Pfam
 PF10559; Plug_translocon
 PF00344; SecY 
SMART
  
PROSITE
 PS00755; SECY_1
 PS00756; SECY_2 
PRINTS