UniProt Accession

 KHDR3_MOUSE; Q9R226; O88624 

Genbank Protein ID

 AF079763; AF099092; BC031507; BC057577 

Genbank Nucleotide ID

 AAC31753.1; AAC72396.1; AAH31507.1; AAH57577.1 

Protein Name

 KH domain-containing, RNA-binding, signal transduction-associated protein 3 

Protein Synonyms/Alias

 RNA-binding protein Etoile; Sam68-like mammalian protein 2; SLM-2 

Gene Name

 Khdrbs3 

Gene Synonyms/Alias

 Salp; Slm2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	YIDVVINKNMKLGQK	ubiquitination	[1]
65	QKVLIPVKQFPKFNF	ubiquitination	[1]
69	IPVKQFPKFNFVGKL	ubiquitination	[1]
75	PKFNFVGKLLGPRGN	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. 

Sequence Annotation

 DOMAIN 61 127 KH.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; SH3-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004087; KH_dom. 

Pfam

  

SMART

 SM00322; KH 

PROSITE

 PS50084; KH_TYPE_1 

PRINTS