UniProt Accession

 ITPA_DROME; Q9VMW7 

Genbank Protein ID

 AE014134; AY071428 

Genbank Nucleotide ID

 AAF52191.1; AAL49050.1 

Protein Name

 Inosine triphosphate pyrophosphatase 

Protein Synonyms/Alias

 ITPase; Inosine triphosphatase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase 

Gene Name

 CG8891 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKPITFVTG	acetylation	[1]
163	KTYAELPKSEKNTIS	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (By similarity). 

Sequence Annotation

 REGION 9 14 Substrate binding (By similarity).
 REGION 67 68 Substrate binding (By similarity).
 REGION 143 146 Substrate binding (By similarity).
 REGION 171 172 Substrate binding (By similarity).
 METAL 39 39 Magnesium or manganese (By similarity).
 METAL 67 67 Magnesium or manganese (By similarity).
 BINDING 51 51 Substrate (By similarity).
 BINDING 166 166 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0009204; P:deoxyribonucleoside triphosphate catabolic process; IEA:HAMAP.
 GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase.
 GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR002637; Ham1p-like.
 IPR027502; ITPase. 

Pfam

 PF01725; Ham1p_like 

SMART

  

PROSITE

  

PRINTS