CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014080
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-interacting protein 1 
Protein Synonyms/Alias
 Rain 
Gene Name
 RASIP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
607GRLARLIKEAVWEKIubiquitination[1]
848VPRTSLLKASWSSLRubiquitination[1, 2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy. 
Sequence Annotation
 DOMAIN 144 259 Ras-associating.
 DOMAIN 600 897 Dilute.
 MOD_RES 328 328 Phosphoserine (By similarity).
 MOD_RES 331 331 Phosphoserine (By similarity).  
Keyword
 Angiogenesis; Complete proteome; Cytoplasm; Golgi apparatus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 963 AA 
Protein Sequence
MLSGERKEGG SPRFGKLHLP VGLWINSPRK QLAKLGRRWP SAASVKSSSS DTGSRSSEPL 60
PPPPPHVELR RVGAVKAAGG ASGSRAKRIS QLFRGSGTGT TGSSGAGGPG TPGGAQRWAS 120
EKKLPELAAG VAPEPPLATR ATAPPGVLKI FGAGLASGAN YKSVLATARS TARELVAEAL 180
ERYGLAGSPG GGPGESSCVD AFALCDALGR PAAAGVGSGE WRAEHLRVLG DSERPLLVQE 240
LWRARPGWAR RFELRGREEA RRLEQEAFGA ADSEGTGAPS WRPQKNRSRA ASGGAALASP 300
GPGTGSGAPA GSGGKERSEN LSLRRSVSEL SLQGRRRRQQ ERRQQALSMA PGAADAQIGT 360
ADPGDFDQLT QCLIQAPSNR PYFLLLQGYQ DAQDFVVYVM TREQHVFGRG GNSSGRGGSP 420
APYVDTFLNA PDILPRHCTV RAGPEHPAMV RPSRGAPVTH NGCLLLREAE LHPGDLLGLG 480
EHFLFMYKDP RTGGSGPARP PWLPARPGAT PPGPGWAFSC RLCGRGLQER GEALAAYLDG 540
REPVLRFRPR EEEALLGEIV RAAAAGSGDL PPLGPATLLA LCVQHSAREL ELGHLPRLLG 600
RLARLIKEAV WEKIKEIGDR QPENHPEGVP EVPLTPEAVS VELRPLMLWM ANTTELLSFV 660
QEKVLEMEKE ADQEDPQLCN DLELCDEAMA LLDEVIMCTF QQSVYYLTKT LYSTLPALLD 720
SNPFTAGAEL PGPGAELGAM PPGLRPTLGV FQAALELTSQ CELHPDLVSQ TFGYLFFFSN 780
ASLLNSLMER GQGRPFYQWS RAVQIRTNLD LVLDWLQGAG LGDIATEFFR KLSMAVNLLC 840
VPRTSLLKAS WSSLRTDHPT LTPAQLHHLL SHYQLGPGRG PPAAWDPPPA EREAVDTGDI 900
FESFSSHPPL ILPLGSSRLR LTGPVTDDAL HRELRRLRRL LWDLEQQELP ANYRHGPPVA 960
TSP 963 
Gene Ontology
 GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0001525; P:angiogenesis; ISS:UniProtKB.
 GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
 GO:0010507; P:negative regulation of autophagy; IMP:BHF-UCL.
 GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0001570; P:vasculogenesis; ISS:UniProtKB. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000253; FHA_dom.
 IPR000159; Ras-assoc.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF01843; DIL
 PF00788; RA 
SMART
 SM00314; RA 
PROSITE
 PS51126; DILUTE
 PS50200; RA 
PRINTS