| Tag | Content |
|---|
| CPLM ID | CPLM-021131 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dysferlin |
Protein Synonyms/Alias | Dystrophy-associated fer-1-like protein; Fer-1-like protein 1 |
Gene Name | Dysf |
Gene Synonyms/Alias | Fer1l1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 245 | RSSAPPRKLLSDKPQ | ubiquitination | [1] | | 250 | PRKLLSDKPQDFQIR | ubiquitination | [1] | | 566 | YAELNTGKGEGVAYR | ubiquitination | [1] | | 1077 | LSQMEALKRHRQAEA | ubiquitination | [1] | | 1566 | PSVIGEFKGLFKIYP | ubiquitination | [1] | | 1693 | LENRLLSKFGARCGL | ubiquitination | [1] | | 1746 | DRVTFQDKDYTIEEI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
Sequence Annotation | DOMAIN 1 85 C2 1.
DOMAIN 209 304 C2 2.
DOMAIN 368 486 C2 3.
DOMAIN 1149 1254 C2 4.
DOMAIN 1575 1673 C2 5. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasmic vesicle; Membrane; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2090 AA |
Protein Sequence | MLCCLLARAS NLPNVKKDRR SDPVASLIFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 60
DQSSELLVVV KDHETMGRNR FLGEAKIPLQ EVLATPSLSA SFNAPLLDAK QQPTGASLVL 120
QVSYTPPPGA VPLFPPPASL APSPTLPDMD LVPGGGQSRA ETWSLLSDST MDTRYSGKKW 180
PVPTDTGGEE DTEDQGLTGD EAEPFLDQSA AVGPGGPTTP RKPPSHPPPH YPGAKRKRSS 240
APPRKLLSDK PQDFQIRVQV IEGRQLPGVN IKPVVKVTAA GQTKRTRIQK GNSPLFNETL 300
FFNVFDSPLE LFDEPIFITV VDSRSLRTDA LLGEFRMDVG TVYREPRHAY LRKWLLLSDP 360
DDFSAGARGY LKASLCVLGP GDEAPLDKKD PSEDKEDIEG NLLRPTGVAL RGAHFCLKLF 420
RAEDLPQMDD AVMDNVKQIF GFDSNKKNLV DPFVEVSFAG KMLCSKILEK TANPQWNQNI 480
TLPAMFPSMC EKMRIRVMDW DRLTHNDTVA TTYLGMSKIS ATGGEIEVDD NLGFLPTFGP 540
CYVNLYGSPR EFTGFPDPYA ELNTGKGEGV AYRGRVLLSL ETKLVEHSEQ KVEDLPADDI 600
LRVEKYLRRR KYSLFAAFYS ATMLQDVDDA IQFEVSIGNY GNKFDTTCLP LASTTQYSRA 660
VFDGCHYYYL PWGNVKPVVV LSSYWEDISH RIEIQNQLLR VADRLEANLE QVHLALKAQC 720
SSEDVDALVA QLTDELLADC SQPLCDIHEI PSATHLDQYL LRLRTRHLSQ IKEAALALKL 780
GHSELSTALE QAEDWLLHLR ALAEEPQNSL PDIIIWMLQG DKRVAYQRVP AHEVLFSRRG 840
PSYCGRNCGK LQTIFLKYPM EGMPGARMPV QIRIKLWFGL SVDEKEFNQF AEGKLSVFAE 900
TYENQTKLAL VGNWGTTGLT YPKFSDVTGK IKLPKDSFRP SAGWAWAGDW FVCPEKTLLH 960
DADAGHLSFV EEVFENQTRL PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS 1020
TDLNRAVDEQ GWEYSITIPP DRKPKHWVPV EKMYYTHRRR RWVRLRRRDL SQMEALKRHR 1080
QAEAEGEGWE YASLFGWKFH LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGMV 1140
DDKSEDSMSV STLSFGVNRP TISCIFDYGN RYHLRCYLYQ ARDLPAMDKD SFSDPYAIVS 1200
FLHQSQKTVV EKNTLNPTWD QTLIFYEIEI FGEPASIAEH PPCIVVELYD HDTYGADEFM 1260
GRCICQPSLE RMPRLAWFPL TRGSQPAGEL LAAFELIQRE KPAIHHIPGF EMHETSRILD 1320
ETEDTDLPYP PPQREANIYM VPQNIKPALQ RTAIEILAWG LRNMKSYQMA SISSPSLVVE 1380
CGGQTVQSCV IRNLRKNPNF DVCTLFMEVM LPREDLYCPP IVVKVIDNRQ FGRRPVVGQC 1440
TIRSLENFLC DPYSAESPSP QGGPDDVSLL SPGEDVLIDI DDKEPLIPVQ EEEFIDWWSK 1500
FFASVGEREK CGSYLEKDFD TLKVYDTQLE NVEAFGGLSD FCNTFKLYRG RTQEETDDPS 1560
VIGEFKGLFK IYPLPEDPAI PMPPRQFHQL AAQGPQECLV RIYIVRAFGL QPKDPNGKCD 1620
PYIKISIGKK SVSDQDNYIP CTLEPVFGKM FELTCTLPLE KDLKITLYDY DLLSKDEKIG 1680
ETVIDLENRL LSKFGARCGL PQTYCVSGPN QWRDQLRPSQ LLHLFCQQHR IKAPVYRTDR 1740
VTFQDKDYTI EEIEAGRLPN PHLGPVEERL ALHVLQQQGL VPEHVESRPL YSPLQPDIEQ 1800
GKLQMWIDIF PKVLGRPGPP FNITPRKARR FFLRCIIWNT KDVILDDLSL TGEKMSDIYV 1860
KGWMVGFEEH KQKTDVHYRS LGGEGNFNWR FVFPFDYLPA EQVCAVAKKD AFWRLDKTES 1920
KIPARVVFQI WDNDKFSFDD FLGSLQLDLN RMPKPAKTAE KCSLDQLDDT FHPEWFVSLF 1980
EQKTVKGWWP CVTEEGEKKM LAGKLEMTLE IVAESEHEER PAGQGRDEPN MNPKLEDPRR 2040
PDTSFLWFTS PYKTMKFILW RRFRCAIILF IILFILLLFL GVFVYAFPNY AAMKLVKPFR 2100 |
Gene Ontology | GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB. GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030027; C:lamellipodium; IDA:UniProtKB. GO:0030315; C:T-tubule; IDA:MGI. GO:0005544; F:calcium-dependent phospholipid binding; IEA:Compara. GO:0001778; P:plasma membrane repair; IMP:UniProtKB. GO:0006906; P:vesicle fusion; IMP:UniProtKB. |
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