CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein zwilch homolog 
Protein Synonyms/Alias
 hZwilch 
Gene Name
 ZWILCH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
326DTEVETLKHDTAAVDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. 
Sequence Annotation
 MOD_RES 88 88 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Kinetochore; Mitosis; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MWERLNCAAE DFYSRLLQKF NEEKKGIRKD PFLYEADVQV QLISKGQPNP LKNILNENDI 60
VFIVEKVPLE KEETSHIEEL QSEETAISDF STGENVGPLA LPVGKARQLI GLYTMAHNPN 120
MTHLKINLPV TALPPLWVRC DSSDPEGTCW LGAELITTNN SITGIVLYVV SCKADKNYSV 180
NLENLKNLHK KRHHLSTVTS KGFAQYELFK SSALDDTITA SQTAIALDIS WSPVDEILQI 240
PPLSSTATLN IKVESGEPRG PLNHLYRELK FLLVLADGLR TGVTEWLEPL EAKSAVELVQ 300
EFLNDLNKLD GFGDSTKKDT EVETLKHDTA AVDRSVKRLF KVRSDLDFAE QLWCKMSSSV 360
ISYQDLVKCF TLIIQSLQRG DIQPWLHSGS NSLLSKLIHQ SYHGTMDTVS LSGTIPVQML 420
LEIGLDKLKK DYISFFIGQE LASLNHLEYF IAPSVDIQEQ VYRVQKLHHI LEILVSCMPF 480
IKSQHELLFS LTQICIKYYK QNPLDEQHIF QLPVRPTAVK NLYQSEKPQK WRVEIYSGQK 540
KIKTVWQLSD SSPIDHLNFH KPDFSELTLN GSLEERIFFT NMVTCSQVHF K 591 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0007093; P:mitotic cell cycle checkpoint; IMP:UniProtKB. 
Interpro
 IPR018630; RZZ-complex_zwilch. 
Pfam
 PF09817; DUF2352 
SMART
  
PROSITE
  
PRINTS