CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013428
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein prune homolog 2 
Protein Synonyms/Alias
 BNIP2 motif-containing molecule at the C-terminal region 1 
Gene Name
 Prune2 
Gene Synonyms/Alias
 Bmcc1; Kiaa0367 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2506VIPTKGPKQTELEYKacetylation[1]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
 May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells (By similarity). 
Sequence Annotation
 DOMAIN 2879 3040 CRAL-TRIO.
 MOTIF 109 111 DHH motif (By similarity).  
Keyword
 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3084 AA 
Protein Sequence
MEEFLQRAKS KLDRSKQLEQ VHAVIGPKSC DLDSLISAFT YAYFLDKVSP PGVLCLPVLN 60
IPRTEFNYFT ETRFILEELN IPESFHIFRD EINLHQLNDE GKLSITLVGS HVLGSEDRTL 120
ESAVVRVINP GEQSDGELGF PETSSSLVLK ELLREAPELI TQQLAHLLRG SILFTWMSMD 180
PELPEKQEEI LSILEEQFPN LPPRDDIINV LQESQLSAQG LSLEQTMLKD LKELSDGEIK 240
VAISTVNMTL EDYLLHGNIT SDLKAFTDKF GFDVLILISS FTWEEQQRQQ IAVYSQNLEL 300
CSQICCELEE SQNPCLELEP FECGCDEILV YQQEDPSVTS DQVFLLLKEV INRRCAEMVS 360
NSRTSSTEAV AGSAPLSQGS SGIMELYGSD IEPQPSSVNF IENPPELNDS NQAQADGNID 420
LVSPDSGLAT IRSSRSSKES SVFLSDDSPV GDGGAPHHSL LPGFDSYSPI PEGIVAEEHA 480
HSGEHSEHFD LFNFDSAPIA SEQSQPSSHS ADYSPEDDFP NSDSSEGNLS AGPKGLGEMG 540
INMSNYSSSS LLSEAGKDSL VEFDEEFIQR QESSGDNSER NLSLTCFAGE EPSSPERLKN 600
PGKMIPPTPM NSFVEISPSN EEPTPLYPED IIQNAIDTGH LGPPQARARC RSWWGGLEID 660
SKNVVDTWNA SEQESVFQSP EPWKDPKPEP VERRTSDSTF QPKSLEFSKS DPWESEFGQP 720
ELGNKEAQDQ KEESLQYQHL PTVRPHLTDA SPHGTNHLIE DFAALWHSGH SPTTMPEPWG 780
NPTDAGEAAV TMSFPTWGAF DKEEDNADTL KNTWNLHPTN NETPSGQEPS EWAMGQSGFS 840
FPAADLLDNP LIEVNKDAAP EIWGKNNSSK DTSLTSGSPT SDLGQTWNNS KLPGEDQNGL 900
VDPKATGKVY EKEGSWSLFE ESAKKRGADV LAPWEDSFLS YKCSDYSASN IGEDSVPSPL 960
DTNYSTSDSY TSPTYAGDEK EIANKPVDKD NGFEAKDAEF PAEGLEVLAT SSQQSQRNRI 1020
GSGPGNLDMW ALPHTEDKPE GNDAHHPDSD ALKTEHAEDK NASMEDDVRE SSPSSYDDPS 1080
MMRLYEANRQ LTLLHSNTNS RQAAPDSLDT WNRVTLEDTQ STATISDMDN DLDWDDCSGG 1140
VAISGDGQAE GYIAANSEPE TRFSVKQLEP WGTEHQEANQ VDWDLSASAE PTGDPGPSEY 1200
QTLNEKTGQL IANSIWDSVM GDKNMPSFRL PSPPNTVDME HGTWPSESPR HSNGKDSHML 1260
EASRLSESGG LTSQPVNQDT WGDSQGDTAS SVTGLASPEH FAQSDPWTGH TYGQSESEIE 1320
GLVASDCEHL DKEAALGSGV NGAPWAFGKK PRDQEFSSSD AFEHQDISSA SGKISSLSVT 1380
SSPQSEEPGE ALEVEKEPFI LDSLAVQTET FTWDLQSKDT HEESLVDHRN LGEANTTLDR 1440
INPMKNRPLS GMELEKTEAC TILKPERANG KLLYESSQDF GVWDGPMDSD VWDSHISYET 1500
AMNSTGQRTE ERSLEALSPG NYDRDSLSSG CTHSSASSPD LHDSSVALSS WTYGPSAEHQ 1560
KENHDDANKQ IHQESELFTT EAHVDVITEM KDFVENREDG FGKMSNQEDP QFPEIPNDPF 1620
NSGPSSSSSS LGADKYSEYS HAYQEGDLTT KRQEENELGF LEIVEPEGTR IISTSSGSGN 1680
DSGGDEELLE KELHLATVAQ SEAGACTSLH EPAFSATEHS KPEFSVFVGS LESIEKENKS 1740
SPFSDSQQSS PGQWILSPLM QADTQDTCKE ETRAAETGTM DTTWHGSAST EAKNGDPDKL 1800
EMLGFSADST EWWNAGAQEG RANAGMSAEE LSNSEGELEP TSPVFQNAGP WSLPIQNDSE 1860
PVDTGSTNPF RGKLKSPVLD SHGDKSQEKL WNIQPKQLDS DANQLSQLVI LDQMKDKDSG 1920
QQTAMSPAAG DLPAETLTQG QGRESMLSVW DRAEPALTHR DENGCVSTGV SPTECQQENQ 1980
WEPEKPYLSH VTHSSTPTEN ALESNAPTQL MRKLDSDWNS PSPSEPQHNF VPDILHGNFE 2040
EGGQLASASP DLWMDVKQPF SFKVDSENPD ILTHCDHDSN SQASSSPDVC HDSEGEQKME 2100
KHTAVYLGLE VEPSEFSLTE PNMNDEPTWE PEQESLPHNS ELHSEHAMPL PPIDSQNDIN 2160
NSSKPASSRS SPEPSDMRGD NNTSVTSMEE DTNPEVEAVD SVTIPGHFPR SEDADTFEAH 2220
QEVSVEVDDS WVSKDLCPES QTGTRALLDC EQPFASESPA VLTDIFLTSD TCLDVSEAAL 2280
DHSFSDASGL NTSTGTIDDM SKLTLSEGHP ETPVDGDAGK QDVCSSEASW GDFEYDAMGQ 2340
NIDEELMREP EHFLYGGDLP SEESALKQSL TPYTPPFDLS YLTEPTGCTE TAQGAESPGD 2400
ESLGSDAAEM LLSALPDHRE EDKAETNIRK PRYQMTVLHI HEDPEALSSP VGGTGSNNES 2460
SPSNIDWEIE TDNSDSPAGG DMKPPNGKEI LELEEDEKVI PTKGPKQTEL EYKEEKQPEQ 2520
SEDHQVLAVD YILVSHEKDS PLKPEAREAR ENIPELEQLS IGSRETGLPE TQLSGTPDTC 2580
QSEFLNDVKV HSAERMSSSS NHESASLENP AQDQSWMVLS HSEVGDPPTE TRDSGPESPG 2640
RTPEPFLSLS LDKGPKSQVL ERNKPLNSLA LEEVAGLSSQ SRNIERQGQA GLDAVPTQAA 2700
THDNEWEMLS PQLSRKNRNP PQEMEEETQC PEPGPRKPRL KGPPSEDEGM DIHFEEGVLS 2760
PSAADMRPEP PNSLDLNGSH PRRIKLTAPN INLSLDQSEG SILSDDNLDS PDEIDINVDE 2820
LDTPDEADSF EYTNHEDPTA NKSSGQESES IPEYTAEEER EDNRLWRTVV IGEQEQRIDM 2880
KVIEPYRRVI SHGGYYGDGL NAIIVFAACF LPDSSRADYH YVMENLFLYV ISTLELMVAE 2940
DYMIVYLNGA TPRRKMPGLG WMKKCYQMID RRLRKNLKSF IIVHPSWFIR TILAVTRPFI 3000
SSKFSSKIKY VTSLSELSGL IPMDCIHIPE SIIKYDEEKS FKRSVRLDEE LREASEAAKT 3060
SCLYNDPEMS SMEKDIDMKL KEKP 3084 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. 
Interpro
 IPR022181; Bcl2-/adenovirus-E1B.
 IPR001251; CRAL-TRIO_dom.
 IPR004097; DHHA2. 
Pfam
 PF12496; BNIP2
 PF02833; DHHA2 
SMART
 SM00516; SEC14 
PROSITE
 PS50191; CRAL_TRIO 
PRINTS