CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031811
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic initiation factor-2 alpha kinase-A 
Protein Synonyms/Alias
 Gcn2alpha, putative 
Gene Name
 TGME49_029630, TGVEG_025870 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
4775DPDTLVLKIVDFGLAacetylation[1]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Initiation factor; Kinase; Lyase; Protein biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5072 AA 
Protein Sequence
MVPWSHLGDA GFLSFSRKYQ DASAPFPPRC ATKQNRGFPP LVSRVSVRLR TPPRLQLAAQ 60
RATNLRLRDA ASRPQFGFRR DASCIVFYGE AKGQSARKKS RRTIPSQRYA QPQCCRCGSR 120
RKLKFNGSQK PRQPLHRPRV ALRFTSLSQR VRSESSARLL SAYTRAGQLS FGISSLTACG 180
AFCLSETQIE FDFVRPRLPF RVEGGSRSAH DTGFSALSSH LLEEPRDREI LWENARVTPA 240
LRESLSAHLS ACRAALTVSR RLFGSGRPAS NPGDRHLKNI FLVDSRWLET AAATERREQR 300
RCMSGWCERV GPSGADVGVS SWTQHRDFEE RRERRDETRR RLVASLSFPK FSSLLAGDAH 360
ARPLDSGALS KPNLFLQAFP FDSNGPQRPC GSRACWTSSL PGREETGRTN WCLSAEALRE 420
CGGRGERPLF VFKRMSKRIR VPALAISPSL LAPPLAALLP AASPLFPFPA ERPCGSASKA 480
GASTIPQTRV ASSSVFSLDL SVDGTASAPV CKHFTPDCLS FCSLSARAPS AVCVLGARVR 540
SVVRLFAGGT RARGELSETG EGAPLERESV ASGESNSRPK IEEVRHRRMT ETRNDRGRSR 600
PQPLRPAGVM PAVCTPSSDP LPVDGVPRLS SRFHFPTHSG LSAARFAKET RDLHFSASPS 660
PLDSSSSSSC SSALRRWKLS SPTQCTRSSR TAVRAGTGCF LLCLILLLVL LAKPAGELQD 720
PEIRWEGGEE PAPRCRVGPY RGSEDSAATE GERRLRFAFE ESEGEGSLAE TTTGPLISRG 780
RRLGPRADCA VSVFESSPLA SRDRKHVSVP HARTSSFQEI TAIHHTAVSS SSAASSRGFS 840
HSSARGETWR ETWRRGEHAP ATFADQFQDL RENEFNLKVK LSMARSDDAG ALARHRRMPP 900
DRGGSRDRFP SFALYRGDRL LPFLRCSSHF RQYSPMLASS PFACGQARSR VSPKLQCRAK 960
EDHAAPERGP SVFSPPHRSQ PRPMQPEIPP STGDEGAGEA VSAVAPSSPH LCVFSHKDPS 1020
GLAPLSSWPE TRSIAVPVPA EAIAPPSANL PAPRVHADDS RAATFCTSSS STANADCVSP 1080
GVSSLLARDA FSDSTLALVS PAGSTVRHRP CPGRARAVDR GDTAGAGPAP VSVSPALGRK 1140
SRRPRLGKGQ RRTDGLDSRE QREASHQGRD TRDRSYTTRL SSPLTDRRRR PLRVPLPSHA 1200
ASAPSVLAED VGDRELFRVP HAVSVGASHS VSCRRAWRSG VGVTGGALPA CQSRERSPEG 1260
EQCCGDNSRG EPRIPGRGSS RHTSETRRKS PREASSKEAP GEHSEGRGVD SSSSSVSAPG 1320
AEAPQNTTQG FSDASREIGS NGSRDSLSEG DAGADMSNSF SSLSPSSFVS SPSSPSHGDI 1380
SSSSSLTAGS VARPFGSSLS RGSLPFSSRL AALVATAAAV AVRSSSPQAV HASAVSTPRS 1440
DGVRDDEGPL SGAVADRELS RSSASLPPLP AESRAERDEL QEPTRPRVSL VLGDARAQTA 1500
TFVESRNGAE ESAVVDREFV PTSASLPLWP SAAVGREAET GDSPHSGWAS SDQSSRLPSF 1560
RGETKGEEWS GERAADAERG SKAHALSTFR GQQPRESPFL AGSLLLSAEA ATLPEPHVGT 1620
HAEEESAEEE RAVAGSGGVN DSIYSTSVEH QAKGLAFPQP PTDHETPSPV SASATSNKQA 1680
DMVSPTSSLP SSLAISAAVP LFARDEGHES PREGVSGGGG RDSGVHSGVS ETPRIAAEDA 1740
DASDLLASTS GVSLSSSPPI ARFAAASSSS IVPHQVASSA GSLGRGETGG LASEASESRL 1800
SSHGPSSLLE ERERGRQREG DARAGLQSLI VLSITGDLYH VTTNGSFVWQ RSLGSSLATA 1860
FDLEPETSSS EDEPRRASTG PKKPRGDAEP RRSPKSPEAP GAQGPPRAAA RVEDRGTSEL 1920
AQTGLGRRLL PAHDGSLFFL DDDGSLTALH VSIPEVVNHL PFQAPLFPHV YFTGEREVRV 1980
TALDLETGQP IAGHRRRGRA RGKGLRAKSS RQGARDRRTR RPRAPLAREP KRHGDSGGDR 2040
GGVEEEAGSR EEVQILEDGS RRVRRDESRE KPFVFESLSL APRPEDVQEN QETAETISGE 2100
DDSEEETDEP RQLQFGVTVW KLWAVDNKAH TTQWGLKWVE VDALGSLTSP GAAPSSRVAY 2160
LRNILRVDDD KLYLLPSPSF SSSPLGRVET RDGGDEGPAT EGPGDPFPAQ PSSERLTRLR 2220
SSRASPASFA PSFAPFTSTS PSQNTAPLFL KFPAPIAAVY VVGPPDGEGE TEEPARRGDR 2280
EDGRSVLGTS RLVLLSDHEE DGSGDQEVSS DPIRPWGEGT TTRGTAGEPS RMDETGRRLR 2340
DPAKNRRRKG GPGPLVTLEC IVRQWGEGAA AIPFAYVPSS QHAVRGDREA FPAFAPFAFP 2400
SQNAHSYASL LLPSMRRLGG SPGPALAPAP PRLPGHSGRR PAGTYPGDEP FDSLVWRDRE 2460
VALPAPPGPN YLEDLKRPLG EEAHADDSLR DAHDKAGRDS RPHSLLPAPL DFLPTSSVSS 2520
SLVPTDDRSP LSASFSASSL PSSHSSFSAS HASFPSSSLS LSSTPSPAHA PGSQRVLSPY 2580
ALHNFRAPAP VQPVRLSHPE AFASQVTLWS GWESPEFPLD SRMQSFPSGR EKTVRSGALR 2640
EPSGGFDAED GDREENRETA DKMARGVAPR EGDETRKERA RGKETPETDA SVGDGARHAL 2700
NVPQLELSEK EGRALTPGGG TGAAVDEVGT RASPLYGVPP SQLPALYGAF DAAPLSFNPV 2760
LSPVLSVLRR WVGRLTRPSA RFFLLPLLSP EPDEERGSSA ARPDDLLAGK ARRHEGADRA 2820
TVCGVEDREA RSSALFFPSS SLNSFSPSSP SWLTPHAQAP PNYVVSLRPD SRRGDRRACG 2880
AEGRRASSEN GPEPEASPEP GRSWLAPGAW AADLLAPSWA ARLLFLLAAA SSMFVVFRFR 2940
GLVSGLLAGV LGFLVSLAGH PWRPCARVLF LLLPPPLRPR APLAEDGRDG EEREDATDLL 3000
VRPIELQGAC TLLSAEEGAS PGHLRAGRRP SEVEERPGSG VVEDGAVSPH ASGGQLALEA 3060
WSGASEVVAL PRPLSSPVWA TPRTFATPAR SLDFDAFAAS SLDATQNTND GGSALSPTAR 3120
ALQARDARGG RDASWAVPGK TGLRPPDGAS SHGTLSAIAW TGRGGTSREE IQRDQDARGQ 3180
TGAVAWGTET APSAPADVAE DMRRLVLALE SRARKREGLT AEGRESRADS GNRTPMYSCR 3240
TASSVSMVSE DESDRRPQLE ALGDLSSCRE FAAEMGTDVQ TPGEEASPRQ GLAKSQWGDR 3300
GAGRQMRAEE LRLSELRARR KVDFPLVQTV GPPLALPGQG DIRFYRRGSS LAAVSSGGSV 3360
CSSSSFATAP NARGSRRSPA PPLAPGACDP FGRHAGETAT EEGVSVASVL DLRCGEERAA 3420
AESPFSLVSS RSTGERMRRA RAPSSPMELI GERMQSSPFL EAIRSARAFA DEASILPPPL 3480
VAASAGLPGP LPIVAPDSPD ACCAGEEIGF IGAAAPGAGG GGMAFGGGRG RPAEPWEVRG 3540
RGGGEGQARP GDDTHDGIVG GGEGLPEGEK RQTERETVTP IYLPGGRMGG GYAGEMFSAE 3600
EWQRVMFRRA GRRCNSVGQL TVYGGGHEAS RGSTAHARWG MPKPLPPVLP PGVCAEAGAT 3660
PQSDVLPVRP GPVSPRPQTA DERKCGGDSG GSSGGRGTAM GLADPNGGVQ PLIGDVDSAS 3720
ASSPSVRAAS SQAVASRLLP SGIHEVKQET VAVSLPSRGD SDEGATPESR FLTDGVSPSP 3780
IATHPASTLP LGGGLSLAPD EARGSLAHGD ALKALEALSG VTTAYVGSAS GSVGDSANSA 3840
SGAVLKVVNS EVAGVLDPSG LVLTSAARLL MAVGGGHATV EEGGTEQREA GLAGQEVHLA 3900
GAARPGDGLA KSTTHGGGVE GGETEKGPLE VAADGGEGSA AALPPPAAPP VEGGGATGAI 3960
VRAGLNVPEV AVVAPPVSPV PAKVDRGIPP DSSLAKLLEN GRFERTFAIQ KLVGQGGFGV 4020
VYQVRHLLEP GHPIYAVKLI LLRLTLSEDI SLRRDFREVA ANRDLYSKHV VRYYTWWCEE 4080
PRFLPVESLG GSRGALTDRR GVGSSAVRDS GPRASVGVTT LTMSPGCLDS ARGSSRFWME 4140
SREAQKNLRR TIRDSAVCKS RREDLSSSFL AVYRQREECR RQTSGREATG GRGLAGNASG 4200
LWRRQPARRR SLSEASCAST STRRCDTAER EELLAKSQTS HLSSEAKRDE TLRGTLQRRR 4260
RSSFPVESAS QRRQDGRETL PAEFLEFSLR SAKDARSQSR NTRSASADSF SPTKKPERRR 4320
RSSLPLSLSC GSRSREEHRQ LERRRPRATS RYPSRYAGRE RGRSRTDEGW KAEKKLRKSA 4380
RGRRGSESSY TSEKTDLRSW CPRCEKQRSV RPHSFPTAKR RAFSIPALKE RQEEREEEAF 4440
PSWFFEQDED SFLSRGMRIE ESNDHTARAR AHRLLCCSGD SFSDAECTYT NGGSGAFWGA 4500
GAEAPRSLQV SGGCTCRWTS GEETEGPREA SGRGDPPGRG ATKRGERRLS RGGEASELRP 4560
AEARQKTQAR KKGKLRAQEW SGPDVSFDMN CYLNTQERDM VVFEDENSGE SNRASSRRSR 4620
EDADSSRSTA LNGQGRERFS VDEEARREKD KNAEDSRRRG RTRRDLLEAI RPAELAREKR 4680
NGLQPPAKET LYPVVLLIQM EMCNGVTLRE WLDRKDRSTV AMGFVPSSKN RWHSMELELF 4740
KQLMKGIRDI HERGIVHRDL KPENIFVDPD TLVLKIVDFG LAKFIQRENP SGAAAGGAPG 4800
GLEPGGPGGA DGLDLGERNR EKQRQKIKGL LAKARRMGKN MEMSYKGEVI GTPAYAAPEG 4860
GGLCDEKADI YSSALILLEL LCPRFTTVME RVKTLEDFKT SYSVPQHIRL HLHPWYLLMK 4920
EMARPEPQHR PSAYTVLKHV KMLLTPPGDT QPQRVMLLYP EPGSPQLDAS ASPSGALGPL 4980
LSSSPALEPS AFPAEPSFPA PIGSTSPFSS SSSSLGAAET LSFALDDGAS SVAAEECDEA 5040
EKPSAESPGV ETLGDRAYGM RVRQGKGKNE RD 5072 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008440; F:inositol-1,4,5-trisphosphate 3-kinase activity; IEA:EC.
 GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.
 GO:0004456; F:phosphogluconate dehydratase activity; IEA:EC.
 GO:0004651; F:polynucleotide 5'-phosphatase activity; IEA:EC.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0000186; P:activation of MAPKK activity; IEA:GOC.
 GO:0000165; P:MAPK cascade; IEA:GOC. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS