CPLM 1.0 - Compendium of Protein Lysine ModificationTag | Content |
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CPLM ID | CPLM-037475 | UniProt Accession | | Genbank Protein ID | | Genbank Nucleotide ID | | Protein Name | Zinc finger protein 451 | Protein Synonyms/Alias | | Gene Name | ZNF451 | Gene Synonyms/Alias | | Created Date | July 27, 2013 | Organism | Homo sapiens (Human) | NCBI Taxa ID | 9606 | Lysine Modification | Position | Peptide | Type | References |
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191 | HLLLGHLKRFDHSPC | ubiquitination | [1, 2] | 220 | ACVVCYKKFVTQQQY | ubiquitination | [1] | 275 | CSKHMSGKNHFHQSF | ubiquitination | [1] | 283 | NHFHQSFKLGDNKGI | ubiquitination | [1, 2, 3] | 288 | SFKLGDNKGIAHPIS | ubiquitination | [1, 2, 3, 4, 5] | 302 | SFPSFAKKLLISLCK | ubiquitination | [1] | 309 | KLLISLCKDVPFQVK | ubiquitination | [1] | 316 | KDVPFQVKCVACHKT | ubiquitination | [1, 2, 6] | 349 | GPVAVAEKSITQVAE | ubiquitination | [3, 4] | 357 | SITQVAEKFILRGYC | ubiquitination | [1, 3, 6] | 381 | ETSTQNHKQNSGHKV | ubiquitination | [1, 3] | 387 | HKQNSGHKVRVINSV | ubiquitination | [1, 2] | 409 | CHSSEGNKDPSSDLH | ubiquitination | [1] | 423 | HLLLDQSKFSSLKRT | ubiquitination | [4, 6] | 434 | LKRTMSIKESSSLEC | ubiquitination | [1, 2, 3] | 448 | CIAIPKKKMNLKDKS | ubiquitination | [1] | 452 | PKKKMNLKDKSHEGV | ubiquitination | [1] | 454 | KKMNLKDKSHEGVAC | ubiquitination | [1, 2, 3, 4] | 464 | EGVACVQKEKSVVKT | ubiquitination | [1, 2, 3, 4] | 466 | VACVQKEKSVVKTWF | ubiquitination | [3] | 505 | YKCVVCGKVCDDSGV | ubiquitination | [1, 2, 3] | 585 | LDNLTANKPSSAITV | ubiquitination | [1, 3, 4, 5] | 622 | FDSQEYVKQHCMSLA | ubiquitination | [3] | 647 | HCRKPFHKIETLYRH | ubiquitination | [1] | 664 | DEHDNEIKIKYFCGL | ubiquitination | [1, 2, 3, 7] | 706 | EKTETSIKTEDDFPV | ubiquitination | [1, 2, 3, 4] | 731 | CRESYICKVNRKEDY | ubiquitination | [1, 2, 3, 7] | 735 | YICKVNRKEDYSRCL | ubiquitination | [1] | 748 | CLQIMLDKGKLWFRC | ubiquitination | [1, 3] | 750 | QIMLDKGKLWFRCSL | ubiquitination | [1] | 779 | IHQVHKEKSDEEEQQ | ubiquitination | [1, 2, 3, 4, 5] | 790 | EEQQYVIKCGTCTKA | ubiquitination | [1, 2, 3, 5, 7] | 817 | RKHCFLQKPSVAHFG | ubiquitination | [1, 3, 7] | 827 | VAHFGSEKSNLYKFT | ubiquitination | [1, 2, 3, 5, 6] | 832 | SEKSNLYKFTASASH | ubiquitination | [1, 2, 3, 4, 5, 6, 7] | 843 | SASHTERKLKQAINY | ubiquitination | [1] | 845 | SHTERKLKQAINYSK | ubiquitination | [1, 3, 4, 5] | 852 | KQAINYSKSLDMEKG | ubiquitination | [1, 2, 3, 4, 5, 6] | 951 | HPRCSKRKDAADFAI | ubiquitination | [1, 7] | 992 | LELENQFKKTQRPAH | ubiquitination | [1, 3, 4, 5] | 993 | ELENQFKKTQRPAHI | ubiquitination | [1] |
| Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] [2] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] [3] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] [4] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] | Functional Description | | Sequence Annotation | | Keyword | Complete proteome; Reference proteome. | Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL | Protein Length | 1041 AA | Protein Sequence | MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY 60 TDENIKRKDH IDYQKDKVAL TLARLARHVE VEKQQKEEKN RAFREKIDFQ HAHGLQELEF 120 IRGHSDTEAA RLCVDQWLKM PGLKTGTINC GTKSSFRRGG HTWVSGKPIL CPIMHCNKEF 180 DNGHLLLGHL KRFDHSPCDP TITLHGPFFS SFACVVCYKK FVTQQQYRDH LFDKEATDDG 240 HNNNLLPQII QCFACPNCFL LFSRKEECSK HMSGKNHFHQ SFKLGDNKGI AHPISFPSFA 300 KKLLISLCKD VPFQVKCVAC HKTLRSHMEL TAHFRVHCRN AGPVAVAEKS ITQVAEKFIL 360 RGYCPDCNQV FVDETSTQNH KQNSGHKVRV INSVEESVLL YCHSSEGNKD PSSDLHLLLD 420 QSKFSSLKRT MSIKESSSLE CIAIPKKKMN LKDKSHEGVA CVQKEKSVVK TWFCECNQRF 480 PSEDAVEKHV FSANTMGYKC VVCGKVCDDS GVIRLHMSRI HGGAHLNNFL FWCRTCKKEL 540 TRKDTIMAHV TEFHNGHRYF YEMDEVEGET LPSSSTTLDN LTANKPSSAI TVIDHSPANS 600 SPRGKWQCRI CEDMFDSQEY VKQHCMSLAS HKFHRYSCAH CRKPFHKIET LYRHCQDEHD 660 NEIKIKYFCG LCDLIFNVEE AFLSHYEEHH SIDYVFVSEK TETSIKTEDD FPVIETSNQL 720 TCGCRESYIC KVNRKEDYSR CLQIMLDKGK LWFRCSLCSA TAQNLTDMNT HIHQVHKEKS 780 DEEEQQYVIK CGTCTKAFHD PESAQQHFHR KHCFLQKPSV AHFGSEKSNL YKFTASASHT 840 ERKLKQAINY SKSLDMEKGV ENDLSYQNIE EEIVELPDLD YLRTMTHIVF VDFDNWSNFF 900 GHLPGHLNQG TFIWGFQGGN TNWKPPLNCK IYNYLNRIGC FFLHPRCSKR KDAADFAICM 960 HAGRLDEQLP KQIPFTILSG DQGFLELENQ FKKTQRPAHI LNPHHLEGDM MCALLNSISD 1020 TTKGTQLQSQ CKPPKRRRLH C 1041 | Gene Ontology | | Interpro | | Pfam | | SMART | | PROSITE | | PRINTS | |
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