UniProt Accession

 VAMP3_HUMAN; Q15836 

Genbank Protein ID

 U64520; BT007327; Z98884; BC003570; BC007050 

Genbank Nucleotide ID

 AAB05814.1; AAP35991.1; CAB63146.1; AAH03570.1; AAH07050.1 

Protein Name

 Vesicle-associated membrane protein 3 

Protein Synonyms/Alias

 VAMP-3; Cellubrevin; CEB; Synaptobrevin-3 

Gene Name

 VAMP3 

Gene Synonyms/Alias

 SYB3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	IMRVNVDKVLERDQK	ubiquitination	[1, 2]
42	KVLERDQKLSELDDR	ubiquitination	[1, 2]
66	QFETSAAKLKRKYWW	ubiquitination	[1, 3, 4]
68	ETSAAKLKRKYWWKN	ubiquitination	[1, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. 

Sequence Annotation

 DOMAIN 14 74 v-SNARE coiled-coil homology.
 MOD_RES 44 44 Phosphoserine (By similarity).  

Keyword

 Cell junction; Coiled coil; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Protein transport; Reference proteome; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 100 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0055037; C:recycling endosome; IDA:MGI.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0017156; P:calcium ion-dependent exocytosis; IEA:Compara.
 GO:0006944; P:cellular membrane fusion; TAS:ProtInc.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0001921; P:positive regulation of receptor recycling; ISS:UniProtKB.
 GO:0006461; P:protein complex assembly; TAS:ProtInc.
 GO:0042147; P:retrograde transport, endosome to Golgi; IDA:UniProtKB.
 GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB.
 GO:0006904; P:vesicle docking involved in exocytosis; TAS:ProtInc. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.