CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-1 complex subunit gamma-1 
Protein Synonyms/Alias
 Clathrin assembly protein complex 1 gamma large chain; Clathrin assembly protein large gamma chain; Gamma-adaptin 
Gene Name
 APL4 
Gene Synonyms/Alias
 YPR029C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
214LLIGLNRKKDEDEDEubiquitination[1]
215LIGLNRKKDEDEDEDubiquitination[1]
324AILYETVKTIFSLDLubiquitination[2]
690LEEIFGEKNDIAQVPubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin. 
Sequence Annotation
 DOMAIN 733 832 GAE.  
Keyword
 Complete proteome; Cytoplasm; Cytoplasmic vesicle; Golgi apparatus; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 832 AA 
Protein Sequence
MGSSLRSFIK DVRGAKTLAD ERAIITKQSA KIRTKLRDDH LPHEKRRVNI QKLLYLYILG 60
EKTHFGQVES INLIASDDFV DKRLGYLAAT LLLDESEDLL TLLTNMLNND LHHPNKYAVS 120
LALTSLGFLS SPELARDLYP DVENIIKNSR DPFLLKKALQ CAAKLIFKDV SLLEIFNIED 180
ITKILSSHSI CTHGVLLGVT KIIQSILLIG LNRKKDEDED EDGIDYSNDI LSPLSLLLRD 240
FFIRLENMNS KNIEPGYDVQ GICDPFLQCE IIYTLKLYFQ VGELLNSNNV LDYKDNFCDL 300
LTRIATNTDS TKNSGQAILY ETVKTIFSLD LNQPLRVLGI NILAKFLAGK DNNTKYVSLN 360
TLLKVVPQEP TAVQRHRKFI SHCLQDTDVS IRMRALELSF AILDDSNLVE LVNELMKFLA 420
KQDEDSKDLI IYTIDHLIDT FDTRVVKDES WKLDVFFNIL KLVGSFINYE KINDILIIIN 480
NTSQLSDKSE FLRKMLTISL NGTSAEISEE NIGWQLVLIW CIGEYGDLVL NEGNKNGADI 540
INESSITDYL LTLQELYTAT NLKIINYILT AALKLSVRFH DAKNIEKLRQ LILSYTDSTD 600
LSLQMKSNQY EIFFNQSISV KKIILETMPK FEKITEEQDN GKALSKNLIS NEPVDLLSDL 660
LGEDSKAESK ASTGDNVKPI DILEEIFGEK NDIAQVPKNA NKEESINHSS AVEANSGVTL 720
PLDANKIYDS SSLNVYASLL SANSGLAHLD LYFQAKSLIS DLKTFCAVPK AQKLTLGQLY 780
PSSTINASQI CKQSLKISGS GKLKLRVKLD FHLNGSSSIT NEQFDHKFDE TL 832 
Gene Ontology
 GO:0030121; C:AP-1 adaptor complex; IPI:SGD.
 GO:0030276; F:clathrin binding; ISS:SGD.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR017107; AP1_complex_gsu.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002553; Clathrin/coatomer_adapt-like_N.
 IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
 IPR008153; Clathrin_g-adaptin_app.
 IPR013041; Coatomer/clathrin_app_Ig-like. 
Pfam
 PF01602; Adaptin_N
 PF02883; Alpha_adaptinC2 
SMART
 SM00809; Alpha_adaptinC2 
PROSITE
 PS50180; GAE 
PRINTS