UniProt Accession

 G6PC_MOUSE; P35576; Q91WV3 

Genbank Protein ID

 U00445; U91573; AK050279; AK052656; AL590969; BC013448 

Genbank Nucleotide ID

 AAC52122.1; AAC53166.1; BAC34162.1; BAC35084.1; CAM19548.1; AAH13448.1 

Protein Name

 Glucose-6-phosphatase 

Protein Synonyms/Alias

 G-6-Pase; G6Pase 

Gene Name

 G6pc 

Gene Synonyms/Alias

 G6pt 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
354	RILGQTHKKSL****	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. 

Sequence Annotation

 MOTIF 354 357 Prevents secretion from ER (Potential).
 ACT_SITE 119 119 Proton donor (Potential).
 ACT_SITE 176 176 Nucleophile (By similarity).
 BINDING 83 83 Substrate (Potential).
 BINDING 170 170 Substrate (Potential).
 CARBOHYD 96 96 N-linked (GlcNAc...) (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Gluconeogenesis; Glycoprotein; Hydrolase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004346; F:glucose-6-phosphatase activity; IDA:MGI.
 GO:0042301; F:phosphate ion binding; IEA:Compara.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
 GO:0051156; P:glucose 6-phosphate metabolic process; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0015760; P:glucose-6-phosphate transport; IDA:MGI.
 GO:0005980; P:glycogen catabolic process; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0008202; P:steroid metabolic process; IMP:MGI.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI.
 GO:0046415; P:urate metabolic process; IMP:MGI. 

Interpro

 IPR016275; Glucose-6-phosphatase.
 IPR016118; P_Acid_Pase/Cl_peroxidase_N.
 IPR000326; P_Acid_Pase_2/haloperoxidase. 

Pfam

 PF01569; PAP2 

SMART

 SM00014; acidPPc 

PROSITE

  

PRINTS