UniProt Accession

 HDEA_ECOLI; P0AES9; P26604; Q2M7H2 

Genbank Protein ID

 D11109; U00039; U00096; AP009048 

Genbank Nucleotide ID

 BAA01883.1; AAB18486.1; AAC76535.1; BAE77784.1 

Protein Name

 Acid stress chaperone HdeA 

Protein Synonyms/Alias

 10K-S protein 

Gene Name

 hdeA 

Gene Synonyms/Alias

 yhhC; yhiB; b3510; JW3478 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
65	EALNNKDKPEDAVLD	acetylation	[1]
91	VQACTQDKQANFKDK	acetylation	[1]
96	QDKQANFKDKVKGEW	acetylation	[1]
105	KVKGEWDKIKKDM**	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non- specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA. 

Sequence Annotation

 DISULFID 39 87  

Keyword

 3D-structure; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Periplasm; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
 GO:0051087; F:chaperone binding; IDA:EcoCyc.
 GO:0071468; P:cellular response to acidity; IMP:EcoCyc. 

Interpro

 IPR024972; HNS-dep_expression_A.
 IPR010486; HNS-dep_expression_A/B. 

Pfam

 PF06411; HdeA 

SMART

  

PROSITE

  

PRINTS