UniProt Accession

 BHA15_RAT; P70562 

Genbank Protein ID

 U58279; AF049874; BC061868 

Genbank Nucleotide ID

 AAC53111.1; AAF17707.1; AAH61868.1 

Protein Name

 Class A basic helix-loop-helix protein 15 

Protein Synonyms/Alias

 bHLHa15; Class B basic helix-loop-helix protein 8; bHLHb8; Muscle, intestine and stomach expression 1; MIST-1 

Gene Name

 Bhlha15 

Gene Synonyms/Alias

 Bhlhb8; Mist1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
40	SGASEVTKGLRSRTA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity). 

Sequence Annotation

 DOMAIN 72 124 bHLH.  

Keyword

 Complete proteome; DNA-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0019722; P:calcium-mediated signaling; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0007030; P:Golgi organization; IEA:Compara.
 GO:0048312; P:intracellular distribution of mitochondria; IEA:Compara.
 GO:0006851; P:mitochondrial calcium ion transport; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS