CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001494
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Latrophilin-1 
Protein Synonyms/Alias
 Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2 
Gene Name
 LPHN1 
Gene Synonyms/Alias
 KIAA0821; LEC2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1159MWNDTVRKQTESSFMubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity). 
Sequence Annotation
 DOMAIN 40 129 SUEL-type lectin.
 DOMAIN 139 398 Olfactomedin-like.
 DOMAIN 799 850 GPS.
 REGION 117 120 Carbohydrate binding (By similarity).
 BINDING 42 42 Carbohydrate (By similarity).
 MOD_RES 1377 1377 Phosphoserine (By similarity).
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 531 531 N-linked (GlcNAc...) (Potential).
 CARBOHYD 640 640 N-linked (GlcNAc...) (Potential).
 CARBOHYD 742 742 N-linked (GlcNAc...) (Potential).
 CARBOHYD 801 801 N-linked (GlcNAc...) (Potential).
 CARBOHYD 806 806 N-linked (GlcNAc...) (Potential).
 CARBOHYD 827 827 N-linked (GlcNAc...) (Potential).
 DISULFID 41 71 By similarity.
 DISULFID 50 128 By similarity.
 DISULFID 83 115 By similarity.
 DISULFID 96 102 By similarity.
 DISULFID 140 322 By similarity.
 DISULFID 480 515 By similarity.
 DISULFID 503 532 By similarity.
 DISULFID 802 833 By similarity.
 DISULFID 821 835 By similarity.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lectin; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Synapse; Synaptosome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1474 AA 
Protein Sequence
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN 60
ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK 120
YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI 180
PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT 240
RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL 300
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL 360
TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT 420
PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP VPSTRRPPAP NLHVSPELFC 480
EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV 540
AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG 600
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF 660
LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE EYPRKNSIQL SAKTIKQNSR 720
NGVVKVVFIL YNNLGLFLST ENATVKLAGE AGPGGPGGAS LVVNSQVIAA SINKESSRVF 780
LMDPVIFTVA HLEDKNHFNA NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN 840
FAVLMAHREI YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC 900
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL LLVEVFESEY 960
SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD NYFIWSFIGP VSFVIVVNLV 1020
FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA LGAIALLFLL GLTWAFGLLF INKESVVMAY 1080
LFTTFNAFQG VFIFVFHCAL QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR 1140
YYTGTQSRIR RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY 1200
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN SYSLRSGDFP 1260
PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA KGPPPPEPPV PPVPGGGGEE 1320
EAGGPGGADR AEIELLYKAL EEPLLLPRAQ SVLYQSDLDE SESCTAEDGA TSRPLSSPPG 1380
RDSLYASGAN LRDSPSYPDS SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY 1440
YQVRRPSHEG YLAAPGLEGP GPDGDGQMQL VTSL 1474 
Gene Ontology
 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; TAS:GDB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0042734; C:presynaptic membrane; ISS:UniProtKB.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0050839; F:cell adhesion molecule binding; ISS:UniProtKB.
 GO:0004930; F:G-protein coupled receptor activity; TAS:GDB.
 GO:0016524; F:latrotoxin receptor activity; ISS:UniProtKB.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
 GO:0007157; P:heterophilic cell-cell adhesion; ISS:UniProtKB.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
 GO:0090129; P:positive regulation of synapse maturation; ISS:UniProtKB. 
Interpro
 IPR022624; DUF3497.
 IPR017981; GPCR_2-like.
 IPR001879; GPCR_2_extracellular_dom.
 IPR003924; GPCR_2_latrophilin.
 IPR003334; GPCR_2_latrophilin_rcpt_C.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom.
 IPR000922; Lectin_gal-bd_dom.
 IPR003112; Olfac-like. 
Pfam
 PF00002; 7tm_2
 PF12003; DUF3497
 PF02140; Gal_Lectin
 PF01825; GPS
 PF02793; HRM
 PF02354; Latrophilin
 PF02191; OLF 
SMART
 SM00303; GPS
 SM00008; HormR
 SM00284; OLF 
PROSITE
 PS00649; G_PROTEIN_RECEP_F2_1
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS
 PS51132; OLF
 PS50228; SUEL_LECTIN 
PRINTS
 PR00249; GPCRSECRETIN.
 PR01444; LATROPHILIN.