CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Origin recognition complex subunit 5 
Protein Synonyms/Alias
 cDNA FLJ53851, highly similar to Origin recognition complex subunit 5 
Gene Name
 ORC5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
103LAVLNFPKYCEPVVKubiquitination[1, 2]
110KYCEPVVKGEASERDubiquitination[1, 2, 3]
130RNIEPHLKKAMQTVYubiquitination[2]
131NIEPHLKKAMQTVYLubiquitination[2]
148ISSSQWEKLQKDDTDubiquitination[1, 2, 4]
151SQWEKLQKDDTDPGQubiquitination[4]
160DTDPGQLKGLSAHTHubiquitination[4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 303 AA 
Protein Sequence
MEANLLPGFL RLQELADRNV TVLFLSEIVW EKFRPNTGCF EPFVLYFPDY SIGNLQKILS 60
HDHPPEYSAD FYAAYINILL GVFYTVCRDL KELRHLAVLN FPKYCEPVVK GEASERDTRK 120
LWRNIEPHLK KAMQTVYLRE ISSSQWEKLQ KDDTDPGQLK GLSAHTHVEL PYYSKFILIA 180
AYLASYNPAR TDKRFFLKHH GKIKKTNFLK KHEKTSNHLL GPKPFPLDRL LAILYSIVDS 240
RVAPTANIFS QITSLVTLQL LTLVGHDDQL DGPKYKCTVS LDFIRAIART VNFDIIKYLY 300
DFL 303 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000808; C:origin recognition complex; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:InterPro. 
Interpro
 IPR020796; ORC5. 
Pfam
  
SMART
  
PROSITE
  
PRINTS