CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021786
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LanC-like protein 2 
Protein Synonyms/Alias
 Testis-specific adriamycin sensitivity protein 
Gene Name
 Lancl2 
Gene Synonyms/Alias
 Tasp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
75KIVPNFIKRIQTKIKubiquitination[1]
82KRIQTKIKDLLQQMEubiquitination[1]
166AVIYHKLKSECESQEubiquitination[1]
177ESQECITKLLQMHRTubiquitination[1]
290ETLTEMVKPSIDYVRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes (By similarity). 
Sequence Annotation
 REGION 2 14 Interaction with inositol phospholipids
 MOD_RES 198 198 Phosphotyrosine.
 MOD_RES 259 259 Phosphotyrosine.
 MOD_RES 295 295 Phosphotyrosine.
 LIPID 2 2 N-myristoyl glycine (By similarity).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Myristate; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MGETMSKRLK FHLGEAEMEE RSFPNPFPDY EAAASAAGLA AGSAEETGRV CPLPTTEDPG 60
LPFHPNGKIV PNFIKRIQTK IKDLLQQMEE GLKTADPHDC SAYTGWTGIA LLYLQLYRVT 120
GDQTYLLRSL DYVKRTLRNL SGRRVTFLCG DAGPLAVGAV IYHKLKSECE SQECITKLLQ 180
MHRTIVCQES ELPDELLYGR AGYLYALLYL NTEIGPGTVG ETAIKEVVSA IIESGKSLSR 240
EERKSERCPL LYQWHRKQYV GAAHGMAGIY YMLMQPEAKV DQETLTEMVK PSIDYVRHKK 300
FRSGNYPSSL SNETDRLVHW CHGAPGVIHV LLQAYQVFKE EKYLKEAMEC SDVIWQRGLL 360
RKGYGICHGT SGNGYSFLSL YRLTQDKKYL YRACKFAEWC LDYGAHGCRI PDRPYSLFEG 420
MAGAVHFLSD ILVPETARFP AFELGFLQKD 450 
Gene Ontology
 GO:0030864; C:cortical actin cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Compara.
 GO:0070273; F:phosphatidylinositol-4-phosphate binding; IEA:Compara.
 GO:0010314; F:phosphatidylinositol-5-phosphate binding; IEA:Compara.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0009789; P:positive regulation of abscisic acid mediated signaling pathway; IEA:Compara. 
Interpro
 IPR008928; 6-hairpin_glycosidase-like.
 IPR012341; 6hp_glycosidase.
 IPR007822; LANC-like.
 IPR020464; LanC-like_prot_euk. 
Pfam
 PF05147; LANC_like 
SMART
  
PROSITE
  
PRINTS
 PR01951; LANCEUKARYTE.
 PR01950; LANCSUPER.