CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015313
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor related to kappa-B-binding protein 
Protein Synonyms/Alias
 DNA-binding protein R kappa-B 
Gene Name
 Nfrkb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
947TNFRIQGKDVLRLPPacetylation[1]
1234TKLIAGNKPVSFLTAacetylation[2, 3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3' (By similarity). 
Sequence Annotation
 REGION 370 495 Winged-helix like domain (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).
 MOD_RES 1019 1019 Phosphoserine (By similarity).
 MOD_RES 1234 1234 N6-acetyllysine (By similarity).
 MOD_RES 1288 1288 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1296 AA 
Protein Sequence
MDSLDHMLTD PLELGPCGDG HSTGIMEDCL LGGTRVSLPE DLLEDPEIFF DVVSLSTWQE 60
VLSDSQREHL QQFLPRFPAD SVEQQRELIL ALFSGENFRF GNPLHIAQKL FRDGHFNPEV 120
VKYRQLCFKS QYKRYLNSQQ QYFHRLLKQI LASRSDLLEM ARRSGPALPF PHKHHSPSRS 180
PEEREWRTQQ RYLKVLREVK EECGDTALSS DEEDLSSWLP SSPARSPSPA VPLRVVPTLS 240
TTDMKTADKI ELGDSDLKLM LKKHHEKRKH QPDHPDLLTG DLTLSDIMTR VNAGRKGSLA 300
ALYDLAVLKK KVKEKEEKKK KKIKLIKSEA EDLAEPLSST EGVPTLSQAP SPLAISSIKE 360
EPLEDIKPCL GINEISSSFF SLLLEILLLE SQASLPMLED RVLDWQSSPA SSLNSWFSAA 420
PNWAELVLPA LQYLAGESRA VPSSFSPFVE FKEKTQQWKL LGQSQDNEKE LAALFHLWLE 480
TKDQAFCKEN EDSSDAMTPV PRVRTDYVVR PSTGEEKRVF QEQERYRYSQ PHKAFTFRMH 540
GFESVVGPVK GVFDKETSLN KAREHSLLRS DRPAYVTILS LVRDAAARLP NGEGTRAEIC 600
ELLKDSQFLA PDVTSTQVNT VVSGALDRLH YEKDPCVKYD IGRKLWIYLH RDRSEEEFER 660
IHQAQAAAAK ARKALQQKPK PPSKVKSSNK EGSTKGLSGP SEQSQMSLSD SSMPPTPVTP 720
VTPTTPALPT PISPPPVSAV NRSGSSTVSE PAQSSSGVLL VSSPTMPQLG TMLSPASIQT 780
PPSSQATARV VSHSSSAGLP QVRVVAQPSL PAVSQQSVGP AQPLPQMPAG PQIRVPVTAT 840
QTKVVPQAVM ATVPVKGQTA AASVQRPGPG QTGLTVTNLP AAVSPVSKTA MSSPGNSAPS 900
ASTTAVIQNV TGQNIIKQVS ITGQLGVKPQ TGSSIPLTAT NFRIQGKDVL RLPPSSITTD 960
AKGQTVLRIT PDMMATLAKS QVTTVKLTQD LFGAGSGTAG KGISATLHVT SNPVHAADSP 1020
AKAPSASVPS SAPAGTTVVK VTPDLKPTET ANSAFRLMPA LGVSVADQKG KNTVASSEAK 1080
PAATIRIVQG LGVMPPKAGQ TITVAAHAKQ GASVAGGSGT VHSSTVSLPS INAAVSKTVA 1140
VASGATSTPI SIGTGAPTVR QVPVNTTVVS TSQSGKLPTR ITVPLSVISQ PMKGKSVVTA 1200
PIIKGNLGAN LSGLGRNIIL TTMPAGTKLI AGNKPVSFLT AQQLQQLQQQ GQATQVRIQT 1260
VPASHLQQGT ASGSSKAVST VVVTTAPSPK QAPEQQ 1296 
Gene Ontology
 GO:0031011; C:Ino80 complex; IEA:InterPro.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR024867; NFRKB.
 IPR025220; NFRKB_winged_dom. 
Pfam
 PF14465; NFRKB_winged 
SMART
  
PROSITE
  
PRINTS