CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041864
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldo-keto reductase family 1, member C19 
Protein Synonyms/Alias
 Protein Akr1c19 
Gene Name
 Akr1c19 
Gene Synonyms/Alias
 mCG_114463 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
75KIAAGLVKREDIFLTubiquitination[1]
101LVRSNLEKSLKNLQLacetylation[2]
175FNSRQLEKILNKPGLacetylation[2, 3]
201HLYLNQRKLLNYCKSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
 ACT_SITE 55 55 Proton donor (By similarity).  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MSSKQQCVKL NDGNFIPALG FGTYKPEEVN ENKPLEAIHL ALEAGFRHID TAYVYQTENH 60
VGQAIRSKIA AGLVKREDIF LTTKLWCTFH RPELVRSNLE KSLKNLQLDY ADLYLIHYPV 120
QMKPGEDLFP EDEHGKTLFD TVDICATWEA MEKCKDAGLV KSIGVSNFNS RQLEKILNKP 180
GLKYKPVCNQ VECHLYLNQR KLLNYCKSKD IVLVAYCALG SQRPKRWVDP SSPVLLNDPI 240
LCDMAKKHKR SPAQIALRYH LQRGIVVLAQ SYKENEIKEN IQVFEFELPS EDMKILDSLD 300
RNLRYAPAPF GEGHPEYPFS DEF 323 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:InterPro. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2 
PRINTS
 PR00069; ALDKETRDTASE.