CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038280
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Herc1 
Protein Synonyms/Alias
  
Gene Name
 Herc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2767FSLRQIAKAMEATGAubiquitination[1]
2879STVTRRHKFDLAARTubiquitination[1]
3309VDDPIQRKFLPSFLRubiquitination[1]
3353KLRPNYDKTEIEKKGubiquitination[1]
3458RVWNVTKKQYSLQQTubiquitination[1]
3835ATCRTALKQQGVLGLubiquitination[1]
4466GKTMVQGKNYGPQITubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4859 AA 
Protein Sequence
MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVTVLYSK LISNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120
YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP 180
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD 240
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVYT MEKNKLLSSQ EGMISFDCFM 300
AILMQMRRSL GSSADRSQWR EPTRTSEGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI 360
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST 420
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF 480
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF 540
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN 600
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE 660
ELAATRIVDI SIGDSHCLSL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI 720
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP 780
FPSSREHHNF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE 840
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA 900
SLLGYSSPSD AADLSTVCMG YGNLSDQPYG SQICHPDTHL AEILMKTLLR NLGFYTDQAF 960
GELEKNSDKY LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNVTENSS SVALLHKHLQ 1020
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP 1080
LLSYLLDLLP PLDCLNRLLP AAALLEDQEL QWPLHGGPEV IDPAGVPLPQ PAQSWVWLVD 1140
LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA 1200
LSGNEEQKPF DYKLRPEVAV YVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL 1260
DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KSLSEVYRCV YKVRSRLLAC KNLELIQTRS 1320
SSRDRWITDN QDSADVDPQE HSFTRTIDEE AEMEELAERD REDGHPEPED EEEEREHEVM 1380
TAGKIFQCFL SAREVARSRD RDRMNSGAGS GVRADDPPPQ SQQERRVSTD LPEGQDVYTA 1440
ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSVSAS EGTGLMTRSE SLTAESRLVH 1500
ASPSYRLIKS RSESDLSQPE SDEEGYALSG RRNVDFDLAS SHRKRGPMHS QLESLSDSWT 1560
RLKHTRDWFY NSSYSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP 1620
QASIIAMEQQ QLRAELRLEA LHQILTLLSG MEEKGNVLLT GSRSSSGFQS STLLTSVRLQ 1680
FLAGCFGLGT VGHTGTKGES GRLHHYQDGI RAAKRNIQVE IQVAVHKIYQ QLSATLERAL 1740
QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP 1800
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK NLLSQTGVLF 1860
MASFGEGEEG EEEEKKVDSS GEAEKRDFRA ALRKQHAAEL HLGDFLVFLR RVVSSKAIQS 1920
KMASPKWTEV LLNIASQKCS SGIPLVGNLR TRLLALHVLE AVLPACESGV EDDQMAQVVE 1980
RLFSLLSDCM WETPIAQAKH AIQIKEKEQE IKLQKQGELE EEDENLPIQE VSFDPEKAQC 2040
CIVENGQILT HGSGGKGYGL ASTGVTSGCY QWKFYIVKEN RGNEGTCVGV SRWPVHDFNH 2100
RTTSDMWLYR AYSGNLYHNG EQTLTLSSFT QGDFITCVLD MEARTISFGK NGEEPKLAFE 2160
DVDAAELYPC VMFYSSNPGE KVKICDMQMR GTPRDLLPGD PICSPVAAVL AEATIQLIRI 2220
LHRTDRWTYC INKKMMERLH KIKICIKESG QKLKKSRSVQ SREENEMREE KENKEEEKGK 2280
HNRHGLADLS EPQLRTLCIE VWPVLAVIGG VDAGLRVGGR CVHKQTGRHA TLLGVVKEGS 2340
TSAKVQWDEA EITISFPTFW SPSDTPLYNL EPCEPLLFDV ARFRGLTASV LLDLTYLTGI 2400
HEDVGKQSIK RHEKKHRHES EEKGDIEQKP ESESILDVRT GLMSDDVKSQ GTTSSKSENE 2460
IASFSLEPTL PGVESQHQIT EGKRKNHEHI SKTHDIAQSE IRAVQLSYLY LGAMKSLSAL 2520
LGCSKYAELL LIPKVLAENG HNSDCASSPV VHEDVEMRAA LQFLMRHMVK RAVMRSPIKR 2580
ALGLADLERA QAMIYKLVVH GLLEDQFGGK IKQEIDQQAE ESDQAQQAQT PVTTSPSASS 2640
TTSFMSSSLE DTTTATTPVT DTETVPASES PGVMPLSLLR QMFSSYPTTT VLPTRRAQTP 2700
PISSLPASPS DEVGRRQSLT SPDSQSTRPA NRTALSDPSS RLSTSPPPPA IAVPLLEMGF 2760
SLRQIAKAME ATGARGEADA QSITVLAMWM IEHPGHEDEE EPQPSSTADS RHGATVLGSG 2820
GKSNDPCYLQ SPGDIPSADA AEMEEGFSES PDNLDHTENA ASGSGPPTRG RSTVTRRHKF 2880
DLAARTLLAR AAGLYRSVQA HRNQSRREGI SLQQDPGALY DFNLDEELEI DLDDEAMEAM 2940
FGQDLTSDND ILGMWIPEVL DWPTWHVCES EDREEVVVCE LCECNVVSFN QHMKRNHPGC 3000
GRSANRQGYR SNGSYVDGWF GGECGSGNPY YLLCGSCREK YLALKTKTKT TNSERYKGQA 3060
PDLIGKQDSV YEEDWDMLDV DEDEKLTGEE EFELLAGPLG LNDRRIVPEP VQFPDSDPLG 3120
ASVAMVTATN SMEETLMQIG CHGSVEKSSS GRVTLGEQAA ALANPHDRVV ALRRVTAAAQ 3180
VLLARTMVMR ALSLLSVSGS SCSLAAGLES LGLTDIRTLV RLMCLAAAGR AGLSTSPSAI 3240
ASTSERSRGG HSKASKPISC LAYLSTAVGC LASNTPSAAK LLVQLCTQNL ISAATGVNLT 3300
TVDDPIQRKF LPSFLRGIAE ENKLVTSPNF VVTQALVALL ADKGAKLRPN YDKTEIEKKG 3360
PLELANALAA CCLSSRLSSQ HRQWAAQQLV RTLAAHDRDN QTAPQTLADM GGDLRKCSFI 3420
KLEAHQNRVM TCVWCNKKGL LATSGNDGTI RVWNVTKKQY SLQQTCVFNR LEGDAEESLG 3480
SPSDPSFSPV SWSISGKYLA GALEKMVNIW QVNGGKGLVD IQPHWVSALA WPEEGPATTW 3540
SGESPELLLV GRMDGSLGLI EVVDVSTMHR RELEHCYRKD VSVTCIAWFS EDRPFAVGYF 3600
DGKLLMGTKE PLEKGGIVLI DAHKETLVSM KWDPTGHILM TCAKEENVKL WGPVSGCWRC 3660
LHSLCHPSTV NGIAWCSLPG KGSKMQLLMA TGCQNGLVCV WRIPQDTTQT SMTSSEGWWD 3720
QESNCQDGYR KSAGAKCVYQ LRGHITPVRT VAFSSDGLAL VSGGLGGLMN IWSLRDGSVL 3780
QTVVIGSGAI QTTVWIPEVG VAACSNRSKD VLVVNCTAEW ASANHILATC RTALKQQGVL 3840
GLNMAPCMRA FLERLPMMLQ EQYAYEKPHV VCGDQLVHSP YMQCLASLAV GLHLDQLLCN 3900
PPVPPHHQNC LPDPTSWNPN EWAWLECFST TIKAAEALTN GAQFPESFTV PDLEPVPEDE 3960
LVLLMDNSKW INGMDEQIMS WATSRPEDWH LGGKCDVYLW GAGRHGQLAE AGRNVMVPAT 4020
APSFSQAQQV ICGQNCTFVI QANGTVLACG EGSYGRLGQG NSDDLHVLTV ISALQGFVVT 4080
QLVTSCGSDG HSMALTESGE VFSWGDGDYG KLGHGNSDRQ RRPRQIEALQ GEEVVQMSCG 4140
FKHSAVVTSD GKLFTFGNGD YGRLGLGNTS NKKLPERVTA LEGYQIGQVA CGLNHTLAVS 4200
ADGSMVWAFG DGDYGKLGLG NSTAKSSPQK VDVLCGIGIK KVACGTQFSV ALTKDGHVYT 4260
FGQDRLIGLP EGRARNHNRP QQIPVLAGVV IEDVAVGAEH TLALASTGDV YAWGSNSEGQ 4320
LGLGHTNHVR EPTLVTVLQG KNIRQISAGR CHSAAWTAPP VPPRAPGVSV PLQLGLPDAV 4380
PPQYGALREV SIHTVRARLR LLYHFSDLMY SSWRLLNLSP NNQNSTSHYN AGTWGIVQGQ 4440
LRPLLAPRVY TLPMVRSIGK TMVQGKNYGP QITVKRISTR GRKCKPIFVQ IARQVVKLNA 4500
SDLRLPSRAW KVKLVGEGAD DAGGVFDDTI TEMCQELETG IVDLLIPSPN ATAEVGYNRD 4560
RFLFNPSACL DEHLMQFKFL GILMGVAIRT KKPLDLHLAP LVWKQLCCVP LTLEDLEEVD 4620
LLYVQTLNSI LHIEDSGITE ESFHEMIPLD SFVGQSADGK MVPIIPGGNS IPLTFSNRKE 4680
YVERAIEYRL HEMDRQVAAV REGMSWIVPV PLLSLLTAKQ LEQMVCGMPE ICVDVLKKVV 4740
RYREVDEQHQ LVQWLWRTLE EFSNEERVLF MRFVSGRSRL PANTADISQR FQIMKVDRPY 4800
DSLPTSQTCF FQLRLPPYSS QLVMAERLRY AINNCRSIDM DNYMLSRNVD NAEGSDTDY 4859 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0010507; P:negative regulation of autophagy; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0031175; P:neuron projection development; IMP:MGI.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR000569; HECT.
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00632; HECT
 PF00415; RCC1
 PF00622; SPRY
 PF00400; WD40 
SMART
 SM00119; HECTc
 SM00449; SPRY
 SM00320; WD40 
PROSITE
 PS50188; B302_SPRY
 PS50237; HECT
 PS00626; RCC1_2
 PS50012; RCC1_3
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00633; RCCNDNSATION.