| Tag | Content |
|---|
| CPLM ID | CPLM-001180 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-mRNA-processing factor 40 homolog A |
Protein Synonyms/Alias | Fas ligand-associated factor 1; Formin-binding protein 11; Formin-binding protein 3; Huntingtin yeast partner A; Huntingtin-interacting protein 10; HIP-10; Huntingtin-interacting protein A; Renal carcinoma antigen NY-REN-6 |
Gene Name | PRPF40A |
Gene Synonyms/Alias | FBP11; FLAF1; FNBP3; HIP10; HYPA; HSPC225 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 169 | EYKSDSGKPYYYNSQ | ubiquitination | [1] | | 393 | ASWEQAMKMIINDPR | ubiquitination | [1] | | 691 | TLDAGNIKLAFNSLL | ubiquitination | [2] | | 700 | AFNSLLEKAEARERE | ubiquitination | [2] | | 749 | DIRERFVKEPAFEDI | ubiquitination | [1] | | 917 | LSEGELEKRRRTLLE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. |
Sequence Annotation | DOMAIN 140 173 WW 1.
DOMAIN 181 214 WW 2.
DOMAIN 393 447 FF 1.
DOMAIN 460 514 FF 2.
DOMAIN 527 587 FF 3.
DOMAIN 607 667 FF 4.
DOMAIN 672 727 FF 5.
DOMAIN 742 799 FF 6.
MOD_RES 36 36 Phosphoserine (By similarity).
MOD_RES 151 151 Phosphoserine.
MOD_RES 196 196 N6-acetyllysine.
MOD_RES 373 373 Phosphothreonine.
MOD_RES 828 828 Phosphoserine (By similarity).
MOD_RES 830 830 Phosphoserine (By similarity).
MOD_RES 832 832 Phosphoserine (By similarity).
MOD_RES 834 834 Phosphoserine (By similarity).
MOD_RES 883 883 Phosphoserine.
MOD_RES 885 885 Phosphoserine.
MOD_RES 888 888 Phosphoserine.
MOD_RES 932 932 Phosphothreonine.
MOD_RES 933 933 Phosphoserine.
MOD_RES 935 935 Phosphoserine.
MOD_RES 938 938 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 957 AA |
Protein Sequence | MCSGSGRRRS SLSPTMRPGT GAERGGLMMG HPGMHYAPMG MHPMGQRANM PPVPHGMMPQ 60
MMPPMGGPPM GQMPGMMSSV MPGMMMSHMS QASMQPALPP GVNSMDVAAG TASGAKSMWT 120
EHKSPDGRTY YYNTETKQST WEKPDDLKTP AEQLLSKCPW KEYKSDSGKP YYYNSQTKES 180
RWAKPKELED LEGYQNTIVA GSLITKSNLH AMIKAEESSK QEECTTTSTA PVPTTEIPTT 240
MSTMAAAEAA AAVVAAAAAA AAAAAAANAN ASTSASNTVS GTVPVVPEPE VTSIVATVVD 300
NENTVTISTE EQAQLTSTPA IQDQSVEVSS NTGEETSKQE TVADFTPKKE EEESQPAKKT 360
YTWNTKEEAK QAFKELLKEK RVPSNASWEQ AMKMIINDPR YSALAKLSEK KQAFNAYKVQ 420
TEKEEKEEAR SKYKEAKESF QRFLENHEKM TSTTRYKKAE QMFGEMEVWN AISERDRLEI 480
YEDVLFFLSK KEKEQAKQLR KRNWEALKNI LDNMANVTYS TTWSEAQQYL MDNPTFAEDE 540
ELQNMDKEDA LICFEEHIRA LEKEEEEEKQ KSLLRERRRQ RKNRESFQIF LDELHEHGQL 600
HSMSSWMELY PTISSDIRFT NMLGQPGSTA LDLFKFYVED LKARYHDEKK IIKDILKDKG 660
FVVEVNTTFE DFVAIISSTK RSTTLDAGNI KLAFNSLLEK AEAREREREK EEARKMKRKE 720
SAFKSMLKQA APPIELDAVW EDIRERFVKE PAFEDITLES ERKRIFKDFM HVLEHECQHH 780
HSKNKKHSKK SKKHHRKRSR SRSGSDSDDD DSHSKKKRQR SESRSASEHS SSAESERSYK 840
KSKKHKKKSK KRRHKSDSPE SDAEREKDKK EKDRESEKDR TRQRSESKHK SPKKKTGKDS 900
GNWDTSGSEL SEGELEKRRR TLLEQLDDDQ 930 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |