UniProt Accession

 MGDP1_HUMAN; Q86V88; Q86Y84; Q8NAD9 

Genbank Protein ID

 AK092821; BC046912; BC051382 

Genbank Nucleotide ID

 BAC03984.1; AAH46912.1; AAH51382.1 

Protein Name

 Magnesium-dependent phosphatase 1 

Protein Synonyms/Alias

 MDP-1 

Gene Name

 MDP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	REIYPGSKITHFERL	ubiquitination	[1]
110	HFERLQQKTGIPFSQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Magnesium-dependent phosphatase which may act as a tyrosine phosphatase (By similarity). 

Sequence Annotation

 ACT_SITE 11 11 Nucleophile (By similarity).
 ACT_SITE 13 13 Proton donor (By similarity).
 METAL 11 11 Magnesium (By similarity).
 METAL 13 13 Magnesium (By similarity).
 METAL 123 123 Magnesium (By similarity).
 BINDING 12 12 Phosphate; via amide nitrogen (By
 BINDING 13 13 Phosphate; via amide nitrogen (By
 BINDING 20 20 Substrate (By similarity).
 BINDING 69 69 Phosphate (By similarity).
 BINDING 70 70 Phosphate (By similarity).
 BINDING 70 70 Substrate (By similarity).
 BINDING 100 100 Phosphate (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 

Interpro

 IPR023214; HAD-like_dom.
 IPR010033; HAD_SF_ppase_IIIC.
 IPR024734; MDP_1_eu.
 IPR010036; MDP_1_eu_arc. 

Pfam

 PF12689; Acid_PPase 

SMART

  

PROSITE

  

PRINTS