| Tag | Content |
|---|
| CPLM ID | CPLM-020681 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar-sorting protein SNF8 |
Protein Synonyms/Alias | ESCRT-II complex subunit VPS22 |
Gene Name | Snf8 |
Gene Synonyms/Alias | D11Moh34 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 134 | QVLKGRGKFAQDVSQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). |
Sequence Annotation | |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Nucleus; Protein transport; Reference proteome; Transcription; Transcription regulation; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 258 AA |
Protein Sequence | MHRRGVGAGA IAKKKLAEAK YKERGTVLAE DQLAQMSKQL DMFKTNLEEF ASKHKQEIRK 60
NPEFRVQFQD MCATIGVDPL ASGKGFWSEM LGVGDFYYEL GVQIIEVCLA LKHRNGGLIT 120
LEELHQQVLK GRGKFAQDVS QDDLIRAIKK LKALGTGFGI IPVGGTYLIQ SVPAELNMDH 180
TVVLQLAEKN GYVTVSEIKT SLKWETERAR QVLEHLLKEG LAWLDLQAPG EAHYWLPALF 240
TDLYSQEISA EEAKEAFP 258 |
Gene Ontology | GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0005667; C:transcription factor complex; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |