| Tag | Content |
|---|
| CPLM ID | CPLM-001101 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
Protein Synonyms/Alias | C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein |
Gene Name | NOS1AP |
Gene Synonyms/Alias | CAPON; KIAA0464 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 96 | KKLLLLQKKEWTWDE | acetylation | [1] | | 97 | KLLLLQKKEWTWDES | acetylation | [1] |
|
Reference | [1] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis. Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A. Anal Chem. 2011 May 15;83(10):3623-6. [ PMID: 21466224] |
Functional Description | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). |
Sequence Annotation | DOMAIN 26 196 PID.
REGION 494 506 Interaction with NOS1 (By similarity).
MOTIF 504 506 PDZ-binding (By similarity).
MOD_RES 188 188 Phosphoserine (By similarity).
MOD_RES 192 192 Phosphoserine (By similarity).
MOD_RES 266 266 Phosphoserine.
MOD_RES 374 374 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 506 AA |
Protein Sequence | MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI CFEAKYVGSL DVPRPNSRVE IVAAMRRIRY 60
EFKAKNIKKK KVSIMVSVDG VKVILKKKKK LLLLQKKEWT WDESKMLVMQ DPIYRIFYVS 120
HDSQDLKIFS YIARDGASNI FRCNVFKSKK KSQAMRIVRT VGQAFEVCHK LSLQHTQQNA 180
DGQEDGESER NSNSSGDPGR QLTGAERAST ATAEETDIDA VEVPLPGNDV LEFSRGVTDL 240
DAVGKEGGSH TGSKVSHPQE PMLTASPRML LPSSSSKPPG LGTETPLSTH HQMQLLQQLL 300
QQQQQQTQVA VAQVHLLKDQ LAAEAAARLE AQARVHQLLL QNKDMLQHIS LLVKQVQELE 360
LKLSGQNAMG SQDSLLEITF RSGALPVLCD PTTPKPEDLH SPPLGAGLAD FAHPAGSPLG 420
RRDCLVKLEC FRFLPPEDTP PPAQGEALLG GLELIKFRES GIASEYESNT DESEERDSWS 480
QEELPRLLNV LQRQELGDGL DDEIAV 506 |
Gene Ontology | GO:0050998; F:nitric-oxide synthase binding; ISS:UniProtKB. GO:0030165; F:PDZ domain binding; ISS:UniProtKB. GO:0042981; P:regulation of apoptotic process; NAS:DFLAT. GO:0045428; P:regulation of nitric oxide biosynthetic process; NAS:DFLAT. GO:0050999; P:regulation of nitric-oxide synthase activity; NAS:DFLAT. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |