| Tag | Content |
|---|
| CPLM ID | CPLM-016435 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein DENND6A |
Protein Synonyms/Alias | DENN domain-containing protein 6A |
Gene Name | Dennd6a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 466 | QKSISPWKSPPQLRQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). |
Sequence Annotation | MOD_RES 124 124 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Endosome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 605 AA |
Protein Sequence | MALPGPAVFG PGSRGSLDEA GAEGREAAAL AAAGVALEDE EEDDGRRGLL RWDGFSAWLH 60
CVCVVGFDLE LGQAVEVIYP QHSKLTDKEK TNICYLSFPD SNSGCLGDTQ FCFRFRQSSG 120
RRVSLHCLLD EFDKDLPVYL KKDPAYFYGY VYFRQVRDKT LKRGYFQKSL VLISKLPYIH 180
FFHTVLKQIA PEYFEKNEPY LEAACNDVDR WPAPVPGKTL HLPIMGLVMK VRIPTCHDKP 240
GTTQMVQLTQ QADTHTSIIL PTVHEVDLFR CFCPVFLHSQ MLWELVLLGE PLVVMAPSPS 300
ESSETVLALV NCISPLKYFS DFRPYFTIHD SEFKEYTTRT QAPPSVILGV TNPFFAKTLQ 360
HWPHIIRIGD LKPAGEIPKQ VKVKKLKNLK TLDSKPGVYT SYKPYLNRDE EIIKQLQKGI 420
QQKRPSEAQS VILRRYFLEL TQSFIIPLER YVASLMPLQK SISPWKSPPQ LRQFLPEEFM 480
KTLEKTGPQL TSGIKGDWIG LYRQFLKSPN FDGWFKTRRK EMTQKLEALH LEALCEEDLL 540
LWIQKHTEVE TVDLVLKLKN KLLQAGRESL PVKPDTVEKL RTHIDAIILA LPDDLQGILL 600
KTGMT 605 |
Gene Ontology | GO:0055037; C:recycling endosome; ISS:UniProtKB. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB. GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |