CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032190
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CTP synthase 1 
Protein Synonyms/Alias
 cDNA FLJ54863, highly similar to CTP synthase 1 (EC 6.3.4.2) 
Gene Name
 CTPS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91FLDIRLTKDNNLTTGubiquitination[1, 2]
99DNNLTTGKIYQYVINubiquitination[1, 2, 3, 4]
107IYQYVINKERKGDYLacetylation[5]
107IYQYVINKERKGDYLubiquitination[1, 2, 3, 4, 6]
176AFRQFQFKVKRENFCubiquitination[1]
200PSSTGEQKTKPTQNSubiquitination[1]
234NPLDTSVKEKISMFCubiquitination[1]
236LDTSVKEKISMFCHVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MPKSKSKMKY ILVTGGVISG IGKGIIASSV GTILKSCGLH VTSIKIDPYI NIDAGTFSPY 60
EHGEVFVLDD GGEVDLDLGN YERFLDIRLT KDNNLTTGKI YQYVINKERK GDYLGKTVQV 120
VPHITDAIQE WVMRQALIPV DEDGLEPQVC VIELGGTVGD IESMPFIEAF RQFQFKVKRE 180
NFCNIHVSLV PQPSSTGEQK TKPTQNSVRE LRGLGLSPDL VVCRCSNPLD TSVKEKISMF 240
CHVEPEQVIC VHDVSSIYRV PLLLEEQGVV DYFLRRLDLP IERQPRKMLM KWKEMADRFA 300
CNEELGVLAS FTLL 314 
Gene Ontology
 GO:0003883; F:CTP synthase activity; IEA:InterPro.
 GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:InterPro. 
Interpro
 IPR004468; CTP_synthase.
 IPR017456; CTP_synthase_N.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06418; CTP_synth_N 
SMART
  
PROSITE
  
PRINTS