UniProt Accession

 F5H1P7_HUMAN; F5H1P7 

Genbank Protein ID

 AL590101 

Genbank Nucleotide ID

  

Protein Name

 TNF receptor-associated factor 5 

Protein Synonyms/Alias

  

Gene Name

 TRAF5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MAYSEEHKGMPCGFI	ubiquitination	[1, 2]
85	VPICPVDKEVIKSQE	ubiquitination	[1]
89	PVDKEVIKSQEVFKD	ubiquitination	[1]
95	IKSQEVFKDNCCKRE	ubiquitination	[1]
100	VFKDNCCKREVLNLY	ubiquitination	[1]
150	HMRLVLEKNVQLEEQ	ubiquitination	[1]
187	KKLEKEFKQFAQLFG	ubiquitination	[1]
247	MEAVDTVKQKITLLE	ubiquitination	[1]
249	AVDTVKQKITLLENN	ubiquitination	[1]
269	VLEEETNKHDTHINI	ubiquitination	[1]
299	EGTCYNGKLIWKVTD	ubiquitination	[1]
387	LLDQSGKKNIMETFK	ubiquitination	[1]
394	KNIMETFKPDPNSSS	ubiquitination	[1]
428	HSVLENAKNAYIKDD	ubiquitination	[1, 2]
433	NAKNAYIKDDTLFLK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 451 AA 

Protein Sequence

Gene Ontology

 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:InterPro.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR002083; MATH.
 IPR012227; TNF_rcpt--assoc_TRAF.
 IPR008974; TRAF-like.
 IPR027130; TRAF5.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00917; MATH
 PF00097; zf-C3HC4 

SMART

 SM00061; MATH
 SM00184; RING 

PROSITE

 PS50144; MATH
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS