CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031331
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysosome-associated membrane glycoprotein 1 
Protein Synonyms/Alias
 cDNA FLJ57633, highly similar to Lysosome-associated membrane glycoprotein 1 
Gene Name
 LAMP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
266DARDPAFKAANGSLRubiquitination[1, 2]
284ATVGNSYKCNAEEHVubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP 60
KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY 120
NLSDTHLFPN ASSKETRCEQ DRPSPTTAPP APPSPSPSPV PKSPSVDKYN VSGTNGTCLL 180
ASMGLQLNLT YERKDNTTVT RLLNINPNKT SASGSCGAHL VTLELHSEGT TVLLFQFGMN 240
ASSSRFFLQG IQLNTILPDA RDPAFKAANG SLRALQATVG NSYKCNAEEH VRVTKAFSVN 300
IFKVWVQAFK VEGGQFGSVE ECLLDENSML IPIAVGGALA GLVLIVLIAY LVGRKRSHAG 360
YQTI 364 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro. 
Interpro
 IPR018134; LAMP_CS.
 IPR002000; Lysosome-assoc_membr_glycop. 
Pfam
 PF01299; Lamp 
SMART
  
PROSITE
 PS00310; LAMP_1
 PS00311; LAMP_2
 PS51407; LAMP_3 
PRINTS
 PR00336; LYSASSOCTDMP.