CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013872
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetylornithine/acetyl-lysine aminotransferase 
Protein Synonyms/Alias
 ACOAT 
Gene Name
 argD 
Gene Synonyms/Alias
 lysJ; TTHA1755 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
320LGPWFMEKLRAIPSPacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
 Involved in both the arginine and lysine biosynthetic pathways (By similarity). 
Sequence Annotation
 REGION 113 114 Pyridoxal phosphate binding.
 REGION 225 228 Pyridoxal phosphate binding.
 BINDING 140 140 Pyridoxal phosphate; via carbonyl oxygen
 BINDING 143 143 N2-acetyl-L-ornithine.
 BINDING 282 282 N2-acetyl-L-ornithine.
 BINDING 283 283 Pyridoxal phosphate.
 MOD_RES 254 254 N6-(pyridoxal phosphate)lysine.  
Keyword
 3D-structure; Amino-acid biosynthesis; Aminotransferase; Arginine biosynthesis; Complete proteome; Cytoplasm; Lysine biosynthesis; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
METRTLEDWR ALLEAEKTLD SGVYNKHDLL IVRGQGARVW DAEGNEYIDC VGGYGVANLG 60
HGNPEVVEAV KRQAETLMAM PQTLPTPMRG EFYRTLTAIL PPELNRVFPV NSGTEANEAA 120
LKFARAHTGR KKFVAAMRGF SGRTMGSLSV TWEPKYREPF LPLVEPVEFI PYNDVEALKR 180
AVDEETAAVI LEPVQGEGGV RPATPEFLRA AREITQEKGA LLILDEIQTG MGRTGKRFAF 240
EHFGIVPDIL TLAKALGGGV PLGAAVMREE VARSMPKGGH GTTFGGNPLA MAAGVAAIRY 300
LERTRLWERA AELGPWFMEK LRAIPSPKIR EVRGMGLMVG LELKEKAAPY IARLEKEHRV 360
LALQAGPTVI RFLPPLVIEK EDLERVVEAV RAVLA 395 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003992; F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; IEA:HAMAP.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
 GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IEA:UniProtKB-UniPathway. 
Interpro
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR004636; Trfase_AcOrn/SuccOrn_fam. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS