CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005343
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarylacetoacetase 
Protein Synonyms/Alias
 FAA; Beta-diketonase; Fumarylacetoacetate hydrolase 
Gene Name
 Fah 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
144VGIMFRGKENALLPNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 133 133 Proton acceptor (Probable).
 METAL 126 126 Calcium (By similarity).
 METAL 199 199 Calcium (By similarity).
 METAL 201 201 Calcium (By similarity).
 METAL 233 233 Calcium (By similarity).
 METAL 233 233 Magnesium (By similarity).
 METAL 253 253 Magnesium (By similarity).
 METAL 257 257 Magnesium (By similarity).
 BINDING 128 128 Substrate (By similarity).
 BINDING 142 142 Substrate (By similarity).
 BINDING 240 240 Substrate (By similarity).
 BINDING 244 244 Substrate (By similarity).
 BINDING 350 350 Substrate (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).  
Keyword
 Acetylation; Calcium; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Phenylalanine catabolism; Reference proteome; Tyrosine catabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 419 AA 
Protein Sequence
MSFIPVAEDS DFPIQNLPYG VFSTQSNPKP RIGVAIGDQI LDLSVIKHLF TGPVLSKHQH 60
VFDETTLNSF MGLGQAAWKE ARASLQNLLS ASQAQLRDDK ELRQRAFTSQ ASATMHLPAT 120
IGDYTDFYSS LQHATNVGIM FRGKENALLP NWLHLPVGYH GRASSVVVSG TPIRRPMGQM 180
RPDNSKPPVY GASKRLDMEL EMAFFVGPGN RFGEPIPISK AQEHIFGMVL MNDWSARDIQ 240
QWEYVPLGPF LGKSFGTTIS PWVVPMDALM PFVVPNPKQD PKPLPYLCHS QPYTFDINLS 300
VALKGEGMSQ AATICRSNFK HMYWTILQQL THHSVNGCNL RPGDLLASGT ISGSDPESFG 360
SMLELSWKGT KAIDVGQGQT RTFLLDGDEV IITGHCQGDG YRVGFGQCAG KVLPALSPA 419 
Gene Ontology
 GO:0004334; F:fumarylacetoacetase activity; TAS:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR005959; Fumarylacetoacetase.
 IPR002529; Fumarylacetoacetase_C.
 IPR011234; Fumarylacetoacetase_C-rel.
 IPR015377; Fumarylacetoacetase_N. 
Pfam
 PF09298; DUF1969
 PF01557; FAA_hydrolase 
SMART
  
PROSITE
  
PRINTS