UniProt Accession

 RS4X_MOUSE; P62702; P12631; P12750; P27576; P55831; Q14727; Q9CXN0 

Genbank Protein ID

 M73436; AK014210; BC009100; M77296 

Genbank Nucleotide ID

 AAA40075.1; BAB29207.1; AAH09100.1; AAA40072.1 

Protein Name

 40S ribosomal protein S4, X isoform 

Protein Synonyms/Alias

  

Gene Name

 Rps4x 

Gene Synonyms/Alias

 Rps4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
16	LKRVAAPKHWMLDKL	acetylation	[1, 2]
22	PKHWMLDKLTGVFAP	acetylation	[1]
53	IFLRNRLKYALTGDE	acetylation	[1]
62	ALTGDEVKKICMQRF	ubiquitination	[3]
71	ICMQRFIKIDGKVRT	ubiquitination	[3]
106	FRLIYDTKGRFAVHR	ubiquitination	[3]
120	RITPEEAKYKLCKVR	acetylation	[4]
120	RITPEEAKYKLCKVR	ubiquitination	[3]
128	YKLCKVRKIFVGTKG	acetylation	[2]
128	YKLCKVRKIFVGTKG	succinylation	[2]
134	RKIFVGTKGIPHLVT	acetylation	[2, 4]
134	RKIFVGTKGIPHLVT	succinylation	[2]
134	RKIFVGTKGIPHLVT	ubiquitination	[3]
155	RYPDPLIKVNDTIQI	ubiquitination	[3]
168	QIDLETGKITDFIKF	ubiquitination	[3]
211	SFDVVHVKDANGNSF	ubiquitination	[3]
233	FVIGKGNKPWISLPR	acetylation	[1, 2, 4, 5]
233	FVIGKGNKPWISLPR	succinylation	[2]
233	FVIGKGNKPWISLPR	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

 DOMAIN 42 104 S4 RNA-binding.  

Keyword

 Complete proteome; Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0005844; C:polysome; IEA:Compara.
 GO:0015935; C:small ribosomal subunit; ISA:MGI.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR005824; KOW.
 IPR000876; Ribosomal_S4e.
 IPR013845; Ribosomal_S4e_central_region.
 IPR013843; Ribosomal_S4e_N.
 IPR018199; Ribosomal_S4e_N_CS.
 IPR002942; S4_RNA-bd. 

Pfam

 PF00467; KOW
 PF00900; Ribosomal_S4e
 PF08071; RS4NT
 PF01479; S4 

SMART

 SM00363; S4 

PROSITE

 PS00528; RIBOSOMAL_S4E
 PS50889; S4 

PRINTS